Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up

doi:10.5312/wjo.v15.i5.457

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May 18, 2024 (publication date) through Nov 28, 2024

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World Journal of Orthopedics

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2218-5836

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Prospective Study

World J Orthop. May 18, 2024; 15(5): 457-468
Published online May 18, 2024. doi: 10.5312/wjo.v15.i5.457

Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up

Madhan Jeyaraman, Naveen Jeyaraman, Tarun Jayakumar, Swaminathan Ramasubramanian, Rajni Ranjan, Saurabh Kumar Jha, Ashim Gupta

Madhan Jeyaraman, Naveen Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu 600077, India

Madhan Jeyaraman, Saurabh Kumar Jha, Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh 201310, India

Madhan Jeyaraman, Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, South Texas Orthopaedic Research Institute, Laredo, TX 78045, United States

Tarun Jayakumar, Department of Orthopaedics, KIMS-Sunshine Hospital, Hyderabad, Telangana 500032, India

Swaminathan Ramasubramanian, Department of Orthopaedics, Government Medical College, Omandurar Government Estate, Chennai, Tamil Nadu 600002, India

Rajni Ranjan, Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh 201306, India

Saurabh Kumar Jha, Department of Zoology, Kalindi College, University of Delhi, New Delhi 110008, India

Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Regenerative Orthopaedics, Noida 201301, Uttar Pradesh, India

Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Future Biologics, Lawrenceville, GA 30043, United States

Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, BioIntegrate, Lawrenceville, GA 30043, United States

Co-corresponding authors: Madhan Jeyaram and Saurabh Kumar Jha.

Author contributions: Jeyaraman M and Jha SK contributed to conceptualization; Jeyaraman M, Jeyaraman N, and Ranjan R contributed to patient screening, acquired clinical data, performed the desired investigation and follow-up; Jeyaraman M, Jayakumar T, and Ramasubramanian S contributed to manuscript writing; Gupta A contributed to manuscript revision; Jeyaraman M, Gupta A, and Jha SK contributed to proofreading; Jha SK contributed to administration. All the authors have read and approved the final manuscript. Jeyaraman M and Jha SK have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. The collaboration between Jeyaraman M and Jha SK is crucial for the publication of this manuscript and other manuscripts still in preparation.

Institutional review board statement: The study was conducted following the Declaration of Helsinki and approved by the Ethics Committee of the School of Medical Sciences and Research, Sharda University (Ref no. SU/SMS&R/76-A/2021/113).

Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.

Conflict-of-interest statement: All authors of this manuscript having no conflicts of interest to disclose.

Data sharing statement: The data is contained within the manuscript.

CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu 600077, India. madhanjeyaraman@gmail.com

Received: January 23, 2024
Revised: March 21, 2024
Accepted: April 18, 2024
Published online: May 18, 2024
Processing time: 113 Days and 4.6 Hours

Core Tip

Core Tip: The clinical study presents a comprehensive analysis of the efficacy of stromal vascular fraction (SVF) in managing knee osteoarthritis, highlighting its superiority over corticosteroid injections in reducing pain and improving joint function. The research emphasizes the need for standardizing SVF therapy protocols to enhance its clinical application.