Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up

Figure 1 Graphical chart. A: Representation of Visual Analog Score over various time-points; B: Representation of International Knee Documentation Committee scores over various time-points. VAS: Visual Analog Score; IKDC: International Knee Documentation Committee.

Figure 2 Magnetic resonance observation of cartilage repair tissue 2. 0 knee score at baseline and 24-month follow-up.

Figure 3 A representational case from group A. A: Pre-procedural radiograph of bilateral knees (anteroposterior (AP) view on standing position) showing decreased medial joint line in bilateral knees suggestive of Kellgren-Lawrence grade II knee osteoarthritis (OA); B: Pre-procedural T2W magnetic resonance imaging (MRI) (coronal section) showing hyperintensity with thinned out cartilage along the medial femoral condyle close to the medial meniscus suggestive of OA knee; C: 2-years follow-up radiograph of bilateral knees (AP view on standing position) showing subtle increase along with the maintenance of medial joint line in bilateral knees; D: 2-years follow-up T2W MRI (coronal image) showing increased cartilaginous thickness with relatively maintained cartilaginous signal indicating response to stromal vascular fraction therapy.

Figure 4 A representational case from group B. A: Pre-procedural radiograph of bilateral knees (anteroposterior (AP) view on standing position) showing decreased medial joint line in bilateral knees suggestive of Kellgren Lawrence grade II knee osteoarthritis (OA); B: Pre-procedural T2W magnetic resonance imaging (MRI) (coronal section) showing hyperintensity with thinned out cartilage along the medial femoral condyle suggestive of OA knee; C: 2-years follow-up radiograph of bilateral knees (AP view on standing position) showing no improvement in the thickness of medial joint line in bilateral knees; D: 2-years follow-up T2W MRI (coronal image) showing no cartilaginous thickness indicating response to corticosteroids therapy.

Figure 5 Graphical abstract demonstrating the summary of the study. SVF: Stromal vascular fraction; VAS: Visual analog score; IKDC: International knee documentation committee; MOCART: Magnetic resonance observation of cartilage repair tissue 2.0 knee score.