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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Jan 18, 2026; 17(1): 112262
Published online Jan 18, 2026. doi: 10.5312/wjo.v17.i1.112262
Published online Jan 18, 2026. doi: 10.5312/wjo.v17.i1.112262
Novel use of bisphosphonates to improve surgical outcomes in experimental bone tuberculosis
Veronika V Petukhova, Alexander Yu Mushkin, Alexey S Maletin, Department of Pediatric Orthopedics and Surgery, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia
Alexander Yu Mushkin, Department of Traumatology and Orthopedic, First Saint Petersburg State Medical University, Saint Petersburg 197022, Russia
Marine Z Dogonadze, Marina E Dyakova, Dilyara S Esmedlyaeva, Research Laboratory of Microbiology, Biochemistry and Immunogenetics, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia
Natalia V Zabolotnykh, Tatiana I Vinogradova, Research Laboratory of Experimental Medicine, Saint-Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg 191036, Russia
Mikhail M Kostik, Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia
Author contributions: Petukhova VV contributed to the literature search and writing original draft; Petukhova VV and Mushkin AY contributed to conceptualization, writing review, and editing; Petukhova VV, Mushkin AY, and Vinogradova TI contributed to design and methodology; Petukhova VV, Mushkin AY, and Kostik MM contributed to formal analysis and interpretation; Petukhova VV, Dogonadze MZ, Zabolotnykh NV, Dyakova ME, and Esmedlyaeva DS contributed to the investigation; Petukhova VV and Kostik MM contributed to validation; Maletin AS contributed to software, resources, and data curation; Mushkin AY and Kostik MM contributed to funding, supervision, project administration, and critical review of the manuscript. All authors have read and agreed to the published version of the manuscript.
Supported by Russian Science Foundation Grant, No. 24-15-00185.
Institutional animal care and use committee statement: The study was approved by the Independent Ethical Committee of the Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health, Russian Federation (Approval No. 74). All animals enrolled in the study completed it according to the protocol, and no deviations or dropouts were recorded. Ethical considerations were thoroughly addressed, including adherence to European Commission guidelines for animal care (2007/526/EC) and national standards (GOST 33215-2014), ensuring humane treatment throughout the experiment. The confirmation certificate regarding animal care and use was issued by the government authority on 10 April 2021, in accordance with national law.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mikhail M Kostik, MD, PhD, Professor, Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Russia. kost-mikhail@yandex.ru
Received: July 23, 2025
Revised: September 4, 2025
Accepted: November 14, 2025
Published online: January 18, 2026
Processing time: 170 Days and 20.4 Hours
Revised: September 4, 2025
Accepted: November 14, 2025
Published online: January 18, 2026
Processing time: 170 Days and 20.4 Hours
Core Tip
Core Tip: A single intravenous dose of pamidronate significantly enhances bone regeneration after surgical treatment of experimental tuberculous osteitis. Pamidronate effectively inhibits early implant resorption, increases osteoblastic activity, and promotes prolonged osteogenesis, showing compatibility and safety when combined with antituberculosis therapy. This finding suggests that bisphosphonates may be a promising adjunctive therapeutic strategy for enhancing clinical outcomes in patients undergoing skeletal tuberculosis surgery.