Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Apr 18, 2024; 15(4): 346-354
Published online Apr 18, 2024. doi: 10.5312/wjo.v15.i4.346
Safety of tranexamic acid in surgically treated isolated spine trauma
Wajiha Zahra, Sandeep Krishan Nayar, Ashwin Bhadresha, Vinay Jasani, Syed Aftab
Wajiha Zahra, Trauma and Orthopedics Department, University Hospital of North Midlands NHS Trust, Stoke-on-Trent ST4 6QG, United Kingdom
Sandeep Krishan Nayar, Ashwin Bhadresha, Trauma and Orthopedics Department, Royal London Hospital, Barts Health Institute, London E1 1BB, United Kingdom
Vinay Jasani, Craniospinal Services, University Hospital of North Midlands NHS Trust, Stoke-on-Trent ST4 6QG, United Kingdom
Syed Aftab, Spine Department, Royal London Hospital, Barts Health Institute, London E1 1BB, United Kingdom
Author contributions: Zahra W, Nayar SK, and Bhadresha A contributed to data collection; Zahra W and Nayar SK contributed to data analysis; Jasani V and Aftab S contributed to supervision; Zahra W, Jasani V and Aftab S contributed to project idea; Zahra W contributed to writing the manuscript and literature review; Nayar SK contributed to review the manuscript; Jasani V and Aftab S contributed to overall supervision.
Institutional review board statement: The project is reviewed and registered with the audit registration team of Royal Stoke University Hospital (No: CA44/21).
Informed consent statement: Informed written consent was obtained from the patients.
Conflict-of-interest statement: We certify that there is no conflict of interest related to the manuscript.
Data sharing statement: Consent was not obtained but the presented data are anonymized.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wajiha Zahra, MBBS, MSc, MRCS, Specialty Registrar Trauma & Orthopedics, University Hospital of North Midlands NHS Trust, Newcastle Road, Stoke-on-Trent ST4 6QG, United Kingdom. wajiha.zahra@nhs.net
Received: November 10, 2023
Peer-review started: November 10, 2023
First decision: January 12, 2024
Revised: February 7, 2024
Accepted: March 19, 2024
Article in press: March 19, 2024
Published online: April 18, 2024
Processing time: 157 Days and 8.9 Hours
Core Tip

Core Tip: Since the introduction of tranexamic acid (TXA), it has been used for reducing blood loss in various surgical specialties such as Urology, general surgery, trauma and orthopedics. TXA use for elective spine surgery is well documented but there is scarce literature to explain the safety of TXA in isolated whole spine trauma. This study looks at the clinical practice of spine surgeons in two major United Kingdom trauma centres and explore the safety of TXA. The study sets the foundation for future research with larger number of patients and to improve the clinical practice.