Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study

Table 1 Clinicodemographic and histological distribution of glioma cases, n (%)

Variables	Values
Age, median (range), years	33.6 (3-75)
Sex
Male	85 (66.4)
Female	43 (33.61)
Histological type
Pilocytic astrocytoma (WHO Grade I)	32 (25)
Oligodendroglioma (WHO Grade II)	38 (29)
Anaplastic astrocytoma (WHO Grade III)	16 (12.5)
Anaplastic oligodendroglioma (WHO Grade III)	10 (7.8)
Glioblastoma (WHO Grade IV)	30 (23.4)
Gliosarcoma (WHO Grade IV)	2 (1.6)

Table 2 Correlation between nestin expression and clinicopathological parameters

	Nestin underexpression	%	Nestin overexpression	%	P value
Tumor grades	Low grade = 19	29.7	Low grade = 45	70.3	0.004
	High grade = 6	9.4	High grade = 58	90.6
Age (years)	> 40 = 31	34.8	> 40 = 58	65.2	0.054
	< 40 = 7	17.9	< 40 = 32	82.1
Gender	Male = 25	29.4	Male = 60	70.6	0.92
	Female = 13	30.2	Female = 30	67.8
Tumor site	Supratentorial = 32	29.6	Supratentorial = 76	70.4	0.973
	Infratentorial = 6	30	Infratentorial = 14	70

Table 3 Survival outcomes stratified by tumor grades and types

Histologic diagnosis	n	Median survival (in months)	95%CI
Low-grade tumors	64	26	20.2-31.8
Pilocytic astrocytoma	32	30	24.7-35.2
Oligodendroglioma	32	18	11.6-24.3
High-grade tumors	64	3	2.0-3.9
Glioblastoma multiforme	16	2	0.8-3.1
Anaplastic astrocytoma	16	4	2.4-5.5
Anaplastic oligodendroglioma	30	2	0.5-3.4
Gliosarcoma	2	2	0.8-3.1

CI: Confidence interval.