Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study

doi:10.5306/wjco.v17.i5.118350

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. May 24, 2026; 17(5): 118350
Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.118350

Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study

Sabeen Nasir, Asif Ali, Ihsan Ullah, Shabnam Wazir, Irum Javaid, Summaya Z Jalal, Ishaq Khan, Muhammed Mubarak

Sabeen Nasir, Department of Pathology, Jinnah Medical College, Khyber Medical University, Peshawar 24840, Khyber Pakhtunkhwa, Pakistan

Asif Ali, Department of Histopathology, Institute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar 25100, Khyber Pakhtunkhwa, Pakistan

Asif Ali, Department of Pathology, College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia

Ihsan Ullah, Department of Pathology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 24840, Khyber Pakhtunkhwa, Pakistan

Shabnam Wazir, Department of Anatomy, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 24840, Khyber Pakhtunkhwa, Pakistan

Irum Javaid, Department of Anatomy, North West School of Medicine, Peshawar 24840, Khyber Pakhtunkhwa, Pakistan

Summaya Z Jalal, Department of Anatomy, Jinnah Medical College, Khyber Medical University, Peshawar 24840, Khyber Pakhtunkhwa, Pakistan

Ishaq Khan, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 24840, Khyber Pakhtunkhwa, Pakistan

Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan

Author contributions: Ali A and Nasir S contributed to conceptualization; Ullah I and Nasir S contributed to data curation; Javaid I and Nasir S contributed to formal analysis; Wazir S and Nasir S contributed to experimentation; Nasir S contributed to methodology and primary drafting; Ali A and Khan I contributed to supervision and validation; Ali A, Jalal SZ, and Mubarak M contributed to critical review for intellectual content and final drafting.

Institutional review board statement: The study was reviewed and approved by the Khyber Medical University, Pakistan, No. KMU/IPMD/IEC/2022/08.

Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.

Data sharing statement: The dataset and related documents are available from the lead author.

Corresponding author: Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com

Received: December 30, 2025
Revised: January 10, 2026
Accepted: March 9, 2026
Published online: May 24, 2026
Processing time: 141 Days and 20.1 Hours

Core Tip

Core Tip: Gliomas show marked biological heterogeneity, necessitating accessible prognostic biomarkers, especially in resource-limited settings. This prospective study demonstrates that nestin overexpression is significantly associated with higher tumour grade and inferior overall survival in both low- and high-grade gliomas. High-grade tumours showed markedly increased nestin expression and substantially shorter survival compared to low-grade counterparts. Patients with high nestin expression experienced poorer outcomes, while the combined analysis revealed the worst prognosis in high-grade gliomas with high nestin levels. These findings highlight nestin as a practical supplementary prognostic marker that may aid risk stratification where advanced molecular testing is unavailable.