Immune checkpoint co-expression combined with systemic inflammatory index: A promising approach in prognostic evaluation of lymphoma in Egypt

Table 1 Co-expression of PD-1/C-X-C motif chemokine receptor 3 or PD-L1/C-X-C motif chemokine receptor 3 in T cells and tumor cells. Expression patterns, clinical significance, and evidence strength

Cell type	Co-express pattern	Significance	Evidence
T cells	Programmed death-1/CXCR3, PD-L1/CXCR3	Strong adverse prognostic markers (associated with advanced disease and short survival). Reflect the exhaustion status and dysfunction of T cells. Dynamic changes can indicate treatment response	Strong; provided specific flow cytometry data, statistical analysis (receiver operating characteristic, survival analysis, multivariate regression), and mechanism discussion
Tumor cells	PD-L1/CXCR3	PD-L1 expression mediates immune escape. Overexpression of CXCR3 may promote tumorigenesis. The two may synergistically promote an immunosuppressive microenvironment	Indirect/inferential; the significance is based on known literature and article background discussion, lacking direct experimental data on co- expression on tumor cells in this article

CXCR3: C-X-C motif chemokine receptor 3; PD-L1: Programmed death-ligand 1.