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World J Clin Oncol. May 24, 2026; 17(5): 117391
Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117391
Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117391
Immune checkpoint co-expression combined with systemic inflammatory index: A promising approach in prognostic evaluation of lymphoma in Egypt
Zu-Chian Chiang, Qi Chen, Biomedical Research Center of South China, Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, Fujian Province, China
Zu-Chian Chiang, College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350117, Fujian Province, China
Ji-Zhen Lin, The Cancer Center, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China
Co-corresponding authors: Ji-Zhen Lin and Qi Chen.
Author contributions: Chiang ZC conceived this editorial, drafted, reviewed, edited the initial manuscript, revised the manuscript, and provided resources and proofreading; Lin JZ and Chen Q drafted the initial manuscript, revised the manuscript, provided resources and funding as co-corresponding authors; all authors have read and approved the final version to be published.
AI contribution statement: Regarding the content conception, ideas/concepts, and logical structure of this manuscript, we have completed them. We utilized DeepSeek’s reading tool to search for relevant scientific literature, read literature, identify typos, and polish related sentences, as well as assist in researching and enriching its content. We didn’t use AI to create graphics, designs, or anything else.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Qi Chen, Professor, Biomedical Research Center of South China, Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, No. 8 Shangsan Road, Cangshan District, Fuzhou 350117, Fujian Province, China. chenqi@fjnu.edu.cn
Received: December 8, 2025
Revised: February 2, 2026
Accepted: March 10, 2026
Published online: May 24, 2026
Processing time: 165 Days and 20.2 Hours
Revised: February 2, 2026
Accepted: March 10, 2026
Published online: May 24, 2026
Processing time: 165 Days and 20.2 Hours
Core Tip
Core Tip: This editorial highlights a novel prognostic model that combines immune checkpoint co-expression and the systemic inflammatory response index. Notably, programmed death-ligand 1/C-X-C motif chemokine receptor 3 co-expression accurately identifies stage IV lymphoma, while systemic inflammatory response index effectively distinguishes advanced disease and decreases with effective treatment. This low-cost biomarker system improves patient stratification, supports treatment monitoring, and promotes healthcare equity in resource-constrained settings.