Untargeted metabolomics analysis of serum metabolic signatures as novel biomarkers for gastric carcinoma

doi:10.5306/wjco.v16.i7.108967

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Jul 24, 2025 (publication date) through Jul 25, 2025

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World Journal of Clinical Oncology

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World J Clin Oncol. Jul 24, 2025; 16(7): 108967
Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.108967

Table 1 Detailed information of top 10 up-regulated differential metabolites

Metabolites	m/z	RT	P value	FDR	log₂FC	VIP
Fenpiclonil	474.97	3.834	1.52E-07	0.00173	1.395	2.690
Methyclothiazide	359.96	6.578	1.03E-06	0.00252	1.308	1.408
5-hydroxyindoleacetate	192.02	6.579	1.92E-06	0.00252	1.578	2.216
3-pyridinecarboxylic acid	294.06	4.380	2.83E-06	0.00252	1.416	1.009
Guanabenz	214.00	6.587	3.56E-06	0.00252	1.488	2.214
2,2-dichloro-n-(3-chloro-1,4-dioxo-2-naphthyl) acetamide	319.97	6.586	4.59E-06	0.00274	1.382	1.639
Benzonitrile	346.99	3.798	7.38E-06	0.00338	1.998	4.299
Epigallocatechin gallate	459.00	3.798	9.76E-06	0.00338	1.545	1.778
Dimethenamid	244.08	4.327	1.01E-05	0.00338	1.549	2.517
Methylene blue	241.00	3.796	1.08E-05	0.00338	0.984	2.417

RT: Retention time; m/z: Mass-to-charge ratio; FDR: False discovery rate; FC: Fold change; VIP: Variable importance projection.

Citation: Ren L, Liu J, Xu YY, Shi ZW. Untargeted metabolomics analysis of serum metabolic signatures as novel biomarkers for gastric carcinoma. World J Clin Oncol 2025; 16(7): 108967
URL: https://www.wjgnet.com/2218-4333/full/v16/i7/108967.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i7.108967