Ren L, Liu J, Xu YY, Shi ZW. Untargeted metabolomics analysis of serum metabolic signatures as novel biomarkers for gastric carcinoma. World J Clin Oncol 2025; 16(7): 108967 [DOI: 10.5306/wjco.v16.i7.108967]
Corresponding Author of This Article
Zhen-Wang Shi, Professor, Department of Gastroenterology, The Second People’s Hospital of Hefei, Heping Road, Hefei 230011, Anhui Province, China. shiyitao99@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jul 24, 2025; 16(7): 108967 Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.108967
Untargeted metabolomics analysis of serum metabolic signatures as novel biomarkers for gastric carcinoma
Le Ren, Jun Liu, Ya-Yun Xu, Zhen-Wang Shi
Le Ren, Zhen-Wang Shi, Department of Gastroenterology, The Second People’s Hospital of Hefei, Hefei 230011, Anhui Province, China
Jun Liu, Department of Ophthalmology, The Third People’s Hospital of Hefei, Hefei 230011, Anhui Province, China
Ya-Yun Xu, Department of Pharmacy, Hefei Fourth People’s Hospital, Hefei 2300000, Anhui Province, China
Co-first authors: Le Ren and Jun Liu.
Author contributions: Ren L, Liu J, Xu YY, and Shi ZW were involved in the conception and design of the study; Ren L and Liu J they contributed equally to this article, they are the co-first authors of this manuscript; Ren L and Xu YY constructed a draft of the manuscript; Shi ZW has provided relevant feedback and critical revisions of the manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The Second People’s Hospital of Hefei, approval No. 2023-keyan-123.
Informed consent statement: All participants in the study provided informed written consent prior to their involvement.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Wang Shi, Professor, Department of Gastroenterology, The Second People’s Hospital of Hefei, Heping Road, Hefei 230011, Anhui Province, China. shiyitao99@163.com
Received: April 27, 2025 Revised: May 14, 2025 Accepted: June 26, 2025 Published online: July 24, 2025 Processing time: 87 Days and 1.3 Hours
Core Tip
Core Tip: We applied untargeted metabolomics to explore serum metabolic profile changes to identify potential serum biomarkers for the diagnosis of gastric carcinoma (GC). Firstly, a substantial alteration in the metabolic profile was observed. Secondly, the serum concentrations of eight metabolites were significantly elevated in 50 GC patients compared to 50 healthy controls. Thirdly, the area under the curve values for eight metabolites exceeded 0.7, indicating their effectiveness in distinguishing GC patients. Fourthly, the serum concentrations of methyclothiazide and epigallocatechin gallate demonstrated a positive correlation with T and N stage, while the serum concentrations of dimethenamid showed a positive correlation with T stage in GC patients.
