MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy: A systematic review

doi:10.5306/wjco.v17.i4.117460

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Apr 24, 2026; 17(4): 117460
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.117460

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Figure 1 Clinical phenotype of chemotherapy-induced peripheral neuropathy.

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Figure 2 Mechanisms of chemotherapy-induced sensory neuron injury. ATP: Adenosine triphosphate; ROS: Reactive oxygen species; TRP: Transient receptor potential (ion channels).

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Figure 3 MicroRNA biogenesis and release in circulation. DROSHA: Drosha ribonuclease III; DGCR8: DiGeorge syndrome critical region gene 8; AGO2: Argonaute 2A; miRISC: MicroRNA-induced silencing complex; DICER: Dicer ribonuclease III; EV: Extracellular vesicle; miRNA: MicroRNA; pre-miRNA: Precursor microRNA.

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Figure 4 Flow diagram illustrating the study selection process.

Citation: Kalamara TV, Andreikos DA, Dodos K, Georgiou E, Fotakopoulos G, Foroglou N, Kapoukranidou D, Georgakopoulou VE. MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy: A systematic review. World J Clin Oncol 2026; 17(4): 117460
URL: https://www.wjgnet.com/2218-4333/full/v17/i4/117460.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i4.117460