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World J Clin Oncol. Apr 24, 2026; 17(4): 117460
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.117460
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.117460
MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy: A systematic review
Tsampika-Vasileia Kalamara, Konstantinos Dodos, Dorothea Kapoukranidou, Laboratory of Physiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Kentrikí Makedonía, Greece
Dimitrios A Andreikos, School of Medicine, Democritus University of Thrace, Alexandroupoli 68100, Anatolikí Makedonía kai Thráki, Greece
Elisavet Georgiou, Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Kentrikí Makedonía, Greece
George Fotakopoulos, Nikolaos Foroglou, Department of Neurosurgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki 54636, Kentrikí Makedonía, Greece
Vasiliki E Georgakopoulou, Department of Pathophysiology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, Athens 11527, Greece
Co-first authors: Tsampika-Vasileia Kalamara and Dimitrios A Andreikos.
Author contributions: Georgakopoulou VE performed the research and analyzed the data and wrote the manuscript; Kalamara TV and Andreikos DA drafted substantial parts of the manuscript, performed the systematic literature search, participated in study selection (titles/abstracts and full texts), extracted, organized and verified data, contributed to the preparation of tables and figures; contributed to data interpretation; and assisted in its critical revision, and they contributed equally to this manuscript as co-first authors; Kalamara TV, Andreikos DA, Dodos K, and Georgakopoulou VE contributed to the design of the study; Dodos K, contributed to methodology; assisted in data extraction and synthesis, critical appraisal of included studies, participated in drafting and revising the methods and discussion sections; Georgiou E contributed to the interpretation of preclinical and translational data, critically reviewed the manuscript for scientific accuracy and coherence; Fotakopoulos G and Kapoukranidou D critically revised the manuscript for important intellectual content; Fotakopoulos G provided clinical expertise in neuro-oncology and chemotherapy-induced peripheral neuropathy, contributed to the interpretation of the clinical relevance of findings; Foroglou N provided neurosurgical and clinical oncology input, contributed to the interpretation of clinical implications and potential translational applications; Kapoukranidou D provided expertise in physiology and neurobiology, contributed to the interpretation of mechanistic aspects of microRNA involvement in chemotherapy-induced peripheral neuropathy. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Vasiliki E Georgakopoulou, MD, PhD, Department of Pathophysiology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, 17 Agiou Toma Street, Athens 11527, Greece. vaso_georgakopoulou@hotmail.com
Received: December 8, 2025
Revised: December 26, 2025
Accepted: March 20, 2026
Published online: April 24, 2026
Processing time: 134 Days and 20.4 Hours
Revised: December 26, 2025
Accepted: March 20, 2026
Published online: April 24, 2026
Processing time: 134 Days and 20.4 Hours
Core Tip
Core Tip: This systematic review synthesizes, for the first time, the human evidence on miRNAs as minimally invasive bio