Colorectal cancer computed tomography imaging features involving microsatellite instability

Figure 1 Histology of colorectal cancer. A: Microsatellite stability colorectal cancer. Slide shows lack of mucin and better glandular differentiation in microsatellite stability colorectal cancer; B: Microsatellite instability-high colorectal cancer. There are small pools of mucin with more dedifferentiated glands.

Figure 2 Inclusion and exclusion criteria.

Figure 3 Example of imaging features. A: This is a computed tomography (CT) abdomen/pelvis with contrast for a 55 years old male with stage 4 microsatellite instability-high colon cancer with ascending colon primary tumor with lymph node metastasis and mesenteric infiltration. This mass was classified as iso-attenuating, heterogeneous, mass-like growth pattern, and ill-defined margins; B: This is a CT abdomen/pelvis with IV contrast for a 73 years old female with microsatellite instability-high stage 4 colon cancer with primary ascending colon tumor measuring 7 cm × 5.1 cm with lymph node metastasis and mesenteric infiltration. This tumor was classified as iso-enhancing, homogeneous, mucosal growth pattern, and well-defined margins; C: This is a CT abdomen/pelvis with IV contrast for a 60 years old female with microsatellite instability-low stage 3 colon cancer with primary sigmoid tumor measuring 2 cm × 1.6 cm without metastasis and without mesenteric infiltration. This tumor was classified as isoattenuating, homogeneous, mucosal growth pattern, and well-defined margins. The arrows point to the site of primary distal sigmoid cancer.