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World J Clin Oncol. Nov 10, 2013; 4(4): 91-101
Published online Nov 10, 2013. doi: 10.5306/wjco.v4.i4.91
Published online Nov 10, 2013. doi: 10.5306/wjco.v4.i4.91
Monitoring adenoviral based gene delivery in rat glioma by molecular imaging
Nadimpalli Ravi S Varma, Branislava Janic, Adarsh Shankar, ASM Iskander, Meser M Ali, Ali S Arbab, Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI 48202, United States
Kenneth N Barton, Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202, United States
Author contributions: Varma NRS and Arbab AS carried out the experimental design, data analysis; Varma NRS carried out the experiments (tumour model development, infections, cell labelling, SPECT imaging) and manuscript writing; Varma NRS, Ali MM and Arbab AS performed the MRI imaging and analysis; Varma NRS, Iskander ASM and Shankar A carried out histological staining and analysis; Barton KN carried out design of viral vectors; Varma NRS and Janic B carried out viral production; Arbab AS carried out the SPECT and MRI image analysis; all authors read and approved the final manuscript.
Supported by NIH Grants 1R21CA129801 (to Arbab AS); R01CA122031 (to Arbab AS)
Correspondence to: Nadimpalli Ravi S Varma, PhD, Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, 1 Ford place, 2F, Box 82, Detroit, MI 48202, United States. ravin@rad.hfh.edu
Telephone: +1-313-8744349 Fax: +1-313-8744494
Received: February 22, 2013
Revised: May 21, 2013
Accepted: July 9, 2013
Published online: November 10, 2013
Processing time: 258 Days and 21.7 Hours
Revised: May 21, 2013
Accepted: July 9, 2013
Published online: November 10, 2013
Processing time: 258 Days and 21.7 Hours
Core Tip
Core tip: Endothelial progenitor cells (EPCs) can be transfected with replication competent adenoviral vector carrying therapeutic/reporter gene and the transfected EPCs can be used to deliver the gene in tumor gene therapy. EPCs can be used as both imaging and therapeutic probes.