DNA methylation in gastric precancerous lesions: Molecular mechanisms and clinical translation

doi:10.5306/wjco.v17.i5.118073

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. May 24, 2026; 17(5): 118073
Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.118073

DNA methylation in gastric precancerous lesions: Molecular mechanisms and clinical translation

Si-Hui Zeng, Yu-Qi Wu, Wei-Jian Zhang, Yi-Tian Wang, Lin Xu, Shao-Ju Guo

Si-Hui Zeng, Wei-Jian Zhang, Yi-Tian Wang, Lin Xu, Shao-Ju Guo, Department of Spleen and Stomach Diseases, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen 518000, Guangdong Province, China

Yu-Qi Wu, Department of Spleen and Stomach Diseases, Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing 210022, Jiangsu Province, China

Author contributions: Zeng SH and Guo SJ designed the research study; Zeng SH, Wu YQ and Zhang WJ performed the literature search, screening, and data extraction; Wang YT and Xu L contributed to critical analysis and interpretation; Zeng SH, Wu YQ and Zhang WJ analyzed the data and wrote the manuscript; Guo SJ acquired the funding; all authors have read and approved the final manuscript.

Supported by National Natural Science Foundation of China, No. 82374348.

Conflict-of-interest statement: All authors declare that they have no conflicts of interest regarding this work.

Corresponding author: Shao-Ju Guo, Professor, Department of Spleen and Stomach Diseases, Shenzhen Hospital of Traditional Chinese Medicine, Fuhua Road, Shenzhen 518000, Guangdong Province, China. gsjgsjgsj2024@163.com

Received: December 23, 2025
Revised: February 12, 2026
Accepted: March 26, 2026
Published online: May 24, 2026
Processing time: 148 Days and 19 Hours

Core Tip

Core Tip: DNA methylation is a pivotal epigenetic driver in gastric precarcinogenesis, orchestrating the stepwise progression from precancerous lesions to cancer. Clinically, methylation biomarkers enable non-invasive early detection, risk stratification, and prognostic assessment. Therapeutically, targeting methylation-regulating enzymes and implementing methylation-guided chemoprevention represent promising precision intervention strategies.