Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Oncol. May 24, 2026; 17(5): 117168
Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117168
Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117168
Hepatic resection in adolescent and young adult patients with hepatocellular carcinoma
Junji Ueda, Akira Matsushita, Yoichi Kawano, Tetsuya Shimizu, Takahiro Murokawa, Hideyuki Takata, Takashi Ono, Daigo Yoshimori, Kazuhiko Endo, Akira Hamaguchi, Hiroshi Yoshida, Department of Gastroenterological Surgery, Nippon Medical School, Bunkyo-ku 113-8603, Tokyo, Japan
Nobuhiko Taniai, Masato Yoshioka, Satoshi Mizutani, Department of Gastrointestinal Surgery, Nippon Medical School Musashi Kosugi Hospital, Kanagawa 211-8533, Kanagawa Ken, Japan
Tomohiro Kanda, Hiroyasu Furuki, Takahiro Haruna, Department of Gastrointestinal Surgery, Nippon Medical School Tama Nagayama Hospital, Tama Shi 206-8512, Tokyo, Japan
Yuto Aoki, Mampei Kawashima, Toshiyuki Irie, Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, Inzai 270-1694, Chiba, Japan
Author contributions: Ueda J, Taniai N, Yoshioka M, Matsushita A, Mizutani S, Kawano Y, Shimizu T, Kanda T, Murokawa T, Takata H, Furuki H, Aoki Y, Kawashima M, Irie T, Ono T, Haruna T, Yoshimori D, Endo K, Hamaguchi A, and Yoshida H conceived and designed the research; Ueda J and Yoshida H drafted the manuscript and conducted the data analysis; Taniai N, Yoshioka M, Matsushita A, Mizutani S, Kawano Y, Shimizu T, Kanda T, Murokawa T, Takata H, Furuki H, Aoki Y, Kawashima M, Irie T, Ono T, Haruna T, Yoshimori D, Endo K, and Hamaguchi A revised the manuscript; all the authors have read and approved the final version to be published.
Institutional review board statement: This study was approved by the Ethics Committee of Nippon Medical School Hospital (Approval No. B-2023-795).
Informed consent statement: Given the retrospective nature of the study, consent was obtained through an optout process approved by the institutional review board.
Conflict-of-interest statement: None of the authors has any relevant financial or nonfinancial interests to disclose.
Data sharing statement:
The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request to junji0821@nms.ac.jp.
Corresponding author: Junji Ueda, MD, PhD, Associate Professor, Department of Gastro
Received: December 1, 2025
Revised: January 23, 2026
Accepted: February 24, 2026
Published online: May 24, 2026
Processing time: 171 Days and 9.5 Hours
Revised: January 23, 2026
Accepted: February 24, 2026
Published online: May 24, 2026
Processing time: 171 Days and 9.5 Hours
Core Tip
Core Tip: This study evaluated the outcomes of hepatic resection in adolescent and young adult (AYA; age 15-39 years) patients with hepatocellular carcinoma (HCC). Among 885 patients who underwent hepatectomy, 9 (1.0%) were classified as AYAs, with hepatitis B virus infection significantly more common and tumors larger in the AYA group than in the non-AYA group. However, tumor marker levels, vascular invasion, differentiation, overall survival, and recurrence-free survival did not differ between the groups. Although rare, AYA HCC showed favorable surgical outcomes, highlighting the im