Stawarz K, Gorzelnik A, Klos W, Korzon J, Kissin F, Bienkowska-Pluta K, Stawarz G, Rusetska N, Zwoliński J. Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study. World J Clin Oncol 2026; 17(4): 116329 [DOI: 10.5306/wjco.v17.i4.116329]
Corresponding Author of This Article
Katarzyna Stawarz, MD, Department of Head and Neck Cancer, Maria Sklodowska-Curie National Research Institute of Oncology, W. K. Roentgen 5, Warsaw 02-781, Mazowieckie, Poland. katarzyna.stawarz@nio.gov.pl
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Oncology
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Retrospective Cohort Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Apr 24, 2026 (publication date) through Apr 22, 2026
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Publication Name
World Journal of Clinical Oncology
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2218-4333
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Stawarz K, Gorzelnik A, Klos W, Korzon J, Kissin F, Bienkowska-Pluta K, Stawarz G, Rusetska N, Zwoliński J. Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study. World J Clin Oncol 2026; 17(4): 116329 [DOI: 10.5306/wjco.v17.i4.116329]
World J Clin Oncol. Apr 24, 2026; 17(4): 116329 Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.116329
Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study
Katarzyna Stawarz, Anna Gorzelnik, Wojciech Klos, Jacek Korzon, Filip Kissin, Karolina Bienkowska-Pluta, Grzegorz Stawarz, Natalia Rusetska, Jakub Zwoliński
Katarzyna Stawarz, Anna Gorzelnik, Wojciech Klos, Jacek Korzon, Filip Kissin, Karolina Bienkowska-Pluta, Jakub Zwoliński, Department of Head and Neck Cancer, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Mazowieckie, Poland
Grzegorz Stawarz, Department of Urology, Warsaw Praski Hospital, Warsaw 03-401, Mazowieckie, Poland
Natalia Rusetska, Department of Experimental Immunology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Mazowieckie, Poland
Author contributions: Stawarz K, Gorzelnik A, Klos W, Bienkowska-Pluta K, Stawarz G and Rusetska N conceptualized the study; Stawarz K, Gorzelnik A, Korzon J, Kissin F, and Stawarz G curated the data; Stawarz K and Stawarz G wrote the original draft; Stawarz K, Stawarz G and Rusetska N developed the methodology; Gorzelnik A, Klos W, Korzon J, Kissin F, Bienkowska-Pluta K, Rusetska N and Zwoliński J reviewed and edited the manuscript; Gorzelnik A, Rusetska N, and Zwoliński J performed the investigation; Zwoliński J supervised the study; all authors have read and agreed to the final version of the manuscript.
Institutional review board statement: The Ethics Committee of the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, waived the need for ethics approval.
Informed consent statement: Informed consent for the information published in this article was not required, as it was waived by the Ethics Committee of the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: All data supporting the findings of this study are available upon reasonable request from the corresponding author.
Corresponding author: Katarzyna Stawarz, MD, Department of Head and Neck Cancer, Maria Sklodowska-Curie National Research Institute of Oncology, W. K. Roentgen 5, Warsaw 02-781, Mazowieckie, Poland. katarzyna.stawarz@nio.gov.pl
Received: November 11, 2025 Revised: November 21, 2025 Accepted: January 26, 2026 Published online: April 24, 2026 Processing time: 164 Days and 13.7 Hours
Core Tip
Core Tip: This study identifies key prognostic factors influencing survival in patients with adenoid cystic carcinoma following surgical treatment. Among 55 patients analyzed, advanced T stage and positive surgical margins independently predicted poorer overall and disease-free survival. Postoperative radiotherapy showed a protective trend, suggesting benefit for local control and long-term outcomes. These findings emphasize the critical importance of achieving negative margins during surgery and integrating radiotherapy into the treatment strategy. By clarifying prognostic determinants, this study contributes valuable evidence to guide individualized, curative management of adenoid cystic carcinoma and improve patient survival in this rare malignancy.
