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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2026; 17(2): 114959
Published online Feb 24, 2026. doi: 10.5306/wjco.v17.i2.114959
Published online Feb 24, 2026. doi: 10.5306/wjco.v17.i2.114959
Lipid metabolism in pancreatic cancer treatment
Chi Zhang, Hao Wang, Yan-Hui Yang, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China
Author contributions: Zhang C wrote the original draft; Zhang C and Wang H contributed to conceptualization, writing, reviewing and editing; Wang H and Yang YH participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Hui Yang, MD, Associate Professor, Chief, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, No. 24 Jinghua Road, Luoyang 471003, Henan Province, China. yangyanhui63@163.com
Received: October 10, 2025
Revised: December 1, 2025
Accepted: January 13, 2026
Published online: February 24, 2026
Processing time: 126 Days and 20.4 Hours
Revised: December 1, 2025
Accepted: January 13, 2026
Published online: February 24, 2026
Processing time: 126 Days and 20.4 Hours
Core Tip
Core Tip: This article highlights lipid metabolism reprogramming as a key driver of pancreatic cancer progression, inducing growth, metastasis, and immunosuppression. Targeting enzymes such as fatty acid synthase or cholesterol pathways shows promise in overcoming therapy resistance, offering innovative strategies to reshape treatment paradigms.