Liu DZ, Wang L, Yang SK, Zhao ZJ, Cui YY, Zhao XK, Zhang F, Guan QH, Zhou L. MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis. World J Clin Oncol 2025; 16(9): 111742 [PMID: 41024852 DOI: 10.5306/wjco.v16.i9.111742]
Corresponding Author of This Article
Lei Zhou, MD, PhD, Full Professor, Department of Biliary-Pancreatic Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou 256603, Shandong Province, China. dr_zhlei@163.com
Research Domain of This Article
Oncology
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Basic Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Sep 24, 2025 (publication date) through Oct 26, 2025
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Publication Name
World Journal of Clinical Oncology
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2218-4333
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Liu DZ, Wang L, Yang SK, Zhao ZJ, Cui YY, Zhao XK, Zhang F, Guan QH, Zhou L. MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis. World J Clin Oncol 2025; 16(9): 111742 [PMID: 41024852 DOI: 10.5306/wjco.v16.i9.111742]
World J Clin Oncol. Sep 24, 2025; 16(9): 111742 Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.111742
MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis
De-Zheng Liu, Lin Wang, Shu-Kuan Yang, Zi-Jian Zhao, Yang-Yang Cui, Xue-Kai Zhao, Fan Zhang, Qing-Hai Guan, Lei Zhou
De-Zheng Liu, Shu-Kuan Yang, Zi-Jian Zhao, Yang-Yang Cui, Fan Zhang, Qing-Hai Guan, Lei Zhou, Department of Biliary-Pancreatic Surgery, Binzhou Medical University Hospital, Binzhou 256603, Shandong Province, China
Lin Wang, Department of Ophthalmology, Binzhou Medical University Hospital, Binzhou 256603, Shandong Province, China
Xue-Kai Zhao, Department of Hepatobiliary Surgery, Binzhou People's Hospital, Binzhou 256603, Shandong Province, China
Author contributions: Liu DZ, Wang L, Yang SK, Zhao ZJ and Zhou L designed the study and drafted the manuscript; Liu DZ, Wang L, Yang SK, Zhao ZJ, Cui YY, Zhao XK, Zhang F, Guan QH and Zhou L performed the research; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 31640052; and Natural Science Foundation of Shandong Province, China, No. ZR2019BH031.
Institutional review board statement: The study was reviewed and approved by Research Ethics Committee of Binzhou Medical University Hospital, No. 2024-S36-001.
Conflict-of-interest statement: The author reports no conflicts of interest in this work.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author, upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Zhou, MD, PhD, Full Professor, Department of Biliary-Pancreatic Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou 256603, Shandong Province, China. dr_zhlei@163.com
Received: July 9, 2025 Revised: July 26, 2025 Accepted: August 22, 2025 Published online: September 24, 2025 Processing time: 77 Days and 5.7 Hours
Core Tip
Core Tip: Aberrant microRNAs expression and associated pathways have been proved participate in regulation vast various physiologic and pathologic processed of different human cancers including liver cancer. In this study, we first provided evidence that miR-451a obviously down-regulated in hepatocellular carcinoma (HCC) tissues and tumor cell lines. Overexpression of miR-451a significantly inhibit human hepatoblastoma G2 (HepG2) cell proliferation, colony formation and migration. However, miR-451a were not participated in HCC cell apoptosis. Moreover, bioinformatic analysis showed that mex-3 RNA binding family member C (MEX3C) was target gene of miR-451a, which validated by reverse transcription-polymerase chain reaction and western blotting. Furthermore, rescue experiments confirmed that overexpression of MEX3C can inhibit the effect of miR-451a in HepG2.
