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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2025; 16(9): 110068
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.110068
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.110068
Prognostic immune nutritional index-based nutritional stratification enhances recovery and survival in gastric cancer: A randomized controlled trial
Gang Wang, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Sheng-Jie Pan, Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Author contributions: Wang G contributed to writing-original draft; Wang G and Pan SJ contributed to conceptualization, supervision, writing-review & editing; All authors have read and approved the final version of the manuscript.
Institutional review board statement: The experimental protocol was established, according to the ethical guidelines of the Helsinki Declaration and was approved by the Human Ethics Committee of the Medical Ethics Committee of the First Affiliated Hospital of Soochow University. Written informed consent was obtained from individual or guardian participants.
Clinical trial registration statement: This clinical trial has been submitted for registration with an internationally recognized registry. The registration application includes all essential trial details, including study objectives, design, intervention protocols, and outcome measures. The trial registration number will be provided upon approval. We affirm that the study was designed and initiated in accordance with ethical and regulatory standards, and full transparency will be maintained upon completion of the registration process.
Informed consent statement: Every human participant gave consent to participate in the study.
Conflict-of-interest statement: All authors have reviewed and approved the final manuscript, and there are no conflicts of interest in the study.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: This study provides all safe and available data, and all data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng-Jie Pan, MD, PhD, Professor, Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. 448331812@qq.com
Received: May 29, 2025
Revised: June 9, 2025
Accepted: August 25, 2025
Published online: September 24, 2025
Processing time: 117 Days and 22.6 Hours
Revised: June 9, 2025
Accepted: August 25, 2025
Published online: September 24, 2025
Processing time: 117 Days and 22.6 Hours
Core Tip
Core Tip: This randomized controlled trial is the first to apply Prognostic Immune Nutritional Index (PINI)-based risk stratification to guide perioperative nutritional support in gastric cancer patients. The tailored interventions significantly improved sleep quality, psychological well-being, nutritional status, and 1-year survival, particularly in high-risk individuals. Our findings highlight the value of individualized immune-enhancing nutrition in optimizing recovery and suggest that PINI may serve as a practical tool for precision perioperative care.