Extracellular vesicles circular RNA: A new perspective and clinical application potential for mediating chemoresistance in colorectal cancer

doi:10.5306/wjco.v16.i7.107633

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World Journal of Clinical Oncology

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World J Clin Oncol. Jul 24, 2025; 16(7): 107633
Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.107633

Extracellular vesicles circular RNA: A new perspective and clinical application potential for mediating chemoresistance in colorectal cancer

Shu-Zhen Liu, Yan Liu, Chao-Li Wang, Yu-Jiao Li, Xiao-Qian Shan, Wei-Li Gao, Mei-Heng He, Lan Zhao

Shu-Zhen Liu, Yan Liu, Chao-Li Wang, Yu-Jiao Li, Xiao-Qian Shan, Wei-Li Gao, Mei-Heng He, Lan Zhao, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China

Shu-Zhen Liu, Yan Liu, Chao-Li Wang, Yu-Jiao Li, Xiao-Qian Shan, Wei-Li Gao, Mei-Heng He, Lan Zhao, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China

Author contributions: Liu SZ was responsible for conceptualization, writing the review, and editing; Liu Y, Wang CL, Li YJ, Shan XQ, Gao WL, and He MH prepared the original draft; Zhao L was responsible for the supervision; All authors contributed to the article and approved the submitted version.

Supported by Open Project of National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, No. NCRCOP2023007.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Lan Zhao, PhD, Research Fellow, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. lanzhao69@163.com

Received: March 28, 2025
Revised: April 29, 2025
Accepted: June 20, 2025
Published online: July 24, 2025
Processing time: 117 Days and 3.4 Hours

Core Tip

Core Tip: Colorectal cancer (CRC) chemoresistance remains a major therapeutic challenge. Circular RNA (circRNA) is enriched and stable in extracellular vesicles (EVs), drives CRC progression, and mediates drug resistance. The circRNA of EVs as a non-invasive biomarker for diagnosis, monitoring, and prognosis offers a promising strategy for precision therapy of CRC.