Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jul 24, 2025; 16(7): 107091
Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.107091
Perceived risk of gastric cancer associated with long-term use of proton pump inhibitors: Bridging the gap
Ibrahim O Sawaied, Abraham O Samson, Efrat Golan
Ibrahim O Sawaied, Abraham O Samson, Azrieli Faculty of Medicine, Bar Ilan University, Safed 21700000, Israel
Efrat Golan, Department of Pediatric Medicine, Haemek Hospital, Afula 2170000, Israel
Author contributions: Sawaied IO designed the study, drafted the manuscript, and coordinated data collection and statistical analysis; Samson AO provided biostatistical analysis, interpretation of data, and critical revision of the manuscript; Golan E contributed to the design of the questionnaire, supervised the research process, and reviewed the final manuscript; All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Azrieli Faculty of Medicine Bar Ilan University, approval No. 06-2023.
Informed consent statement: All participating physicians provided informed consent prior to inclusion in the study. The survey was anonymous and voluntary, and participants were informed about the purpose, procedures, and confidentiality of the data collected.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The dataset generated and analyzed during the current study is available from the corresponding author upon reasonable request. All data have been anonymized to protect participant confidentiality.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ibrahim O Sawaied, Azrieli Faculty of Medicine, Bar Ilan University, Henrietta Szold St 8, Safed 21700000, Israel. ibomsa13@gmail.com
Received: March 16, 2025
Revised: April 11, 2025
Accepted: June 13, 2025
Published online: July 24, 2025
Processing time: 129 Days and 20.1 Hours
Core Tip

Core Tip: This cross-sectional study highlighted a significant gap in physician awareness regarding the long-term risks of proton pump inhibitor use, particularly the association with gastric cancer. While gastroenterologists demonstrated higher awareness, they were also more likely to prescribe proton pump inhibitors long-term. These findings underscore the need for improved clinical guidelines, periodic medication reassessment, and targeted educational interventions to ensure safer prescribing practices and optimize patient care.