Saikia K, Xu Z, Azordegan N, Ahsan BU. Incidental diagnosis of gallbladder carcinoma during or after routine cholecystectomy: A retrospective study with emphasis on clinicopathologic findings. World J Clin Oncol 2025; 16(7): 104663 [DOI: 10.5306/wjco.v16.i7.104663]
Corresponding Author of This Article
Beena Umar Ahsan, MD, Assistant Professor, Department of Pathology and Laboratory Medicine, Henry Ford Health, 2799 W Grand Boulevard, Detroit, MI 48202, United States. bahsan1@hfhs.org
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jul 24, 2025; 16(7): 104663 Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.104663
Incidental diagnosis of gallbladder carcinoma during or after routine cholecystectomy: A retrospective study with emphasis on clinicopathologic findings
Kasturi Saikia, Zhengfan Xu, Nazila Azordegan, Beena Umar Ahsan
Kasturi Saikia, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States
Zhengfan Xu, Nazila Azordegan, Beena Umar Ahsan, Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI 48202, United States
Beena Umar Ahsan, Department of Medicine, Michigan State University College of Human Medicine, East Lansing, MI 48823, United States
Author contributions: Saikia K was responsible for methodology, data analysis, writing the original draft; Xu Z was responsible for data collection, statistical analysis; Azordegan N was responsible for conceptualization, literature review, manuscript editing, supervision; Ahsan BU was responsible for conceptualization, literature review, study design, manuscript editing, supervision.
Institutional review board statement: The study was approved by the Institutional Review Board of Henry Ford Health, Detroit, MI, United States.
Informed consent statement: The waiver of consent was requested due to retrospective nature of the study.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Beena Umar Ahsan, MD, Assistant Professor, Department of Pathology and Laboratory Medicine, Henry Ford Health, 2799 W Grand Boulevard, Detroit, MI 48202, United States. bahsan1@hfhs.org
Received: December 27, 2024 Revised: March 8, 2025 Accepted: June 18, 2025 Published online: July 24, 2025 Processing time: 207 Days and 12.8 Hours
Core Tip
Core Tip: The most common indication for cholecystectomy is acute or chronic cholecystitis with cholelithiasis. However, in rare instances, incidental findings ranging from benign to malignant conditions can be encountered. We performed a retrospective cross-sectional study of patients who had cholecystectomies at our institution for presumed benign gallbladder disease. Our aim was to determine the prevalence of all incidental diagnoses, with a particular emphasis on adenocarcinoma, resulting from pathological analysis of gallbladder specimens in patients for whom malignancy was not suspected preoperatively. This is one of the largest studies for the incidental diagnosis of gallbladder adenocarcinoma with emphasis on histopathologic analysis.
