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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 24, 2025; 16(11): 113193
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.113193
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.113193
Ferroptosis, autophagy, and mitochondrial dynamics: Front burners in cancer therapeutics
Minal Garg, Department of Biochemistry and Director, Institute of Advanced Molecular Genetics and Infectious Diseases, University of Lucknow, Lucknow 226007, Uttar Pradesh, India
Niharika, Department of Biochemistry, University of Lucknow, Lucknow 226007, Uttar Pradesh, India
Co-corresponding authors: Minal Garg and Niharika.
Author contributions: Garg M and Niharika contributed to this paper and have agreed with the submission in its present form.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Minal Garg, Full Professor, Department of Biochemistry and Director, Institute of Advanced Molecular Genetics and Infectious Diseases, University of Lucknow, University Road, Lucknow 226007, Uttar Pradesh, India. garg_minal@lkouniv.ac.in
Received: August 19, 2025
Revised: August 27, 2025
Accepted: October 21, 2025
Published online: November 24, 2025
Processing time: 94 Days and 20.9 Hours
Revised: August 27, 2025
Accepted: October 21, 2025
Published online: November 24, 2025
Processing time: 94 Days and 20.9 Hours
Core Tip
Core Tip: Considering the important regulatory role of ferroptosis, autophagy and its dynamic interplay with mitochondrial metabolism in tumor pathogenesis, therapy resistance and metastasis, reshaping of the tumor microenvironment with the modulations in autophagy and mitochondrial function could sensitize ferroptosis-resistant tumors to anti-cancer drugs thereby increase the therapeutic efficacy of existing treatment regimens.