Han H, Guo XY, Wen JX, Zhao XM, Zhou WQ. Immune regulation of Chidamide-induced Linc01010 accumulation in breast cancer cell death. World J Clin Oncol 2025; 16(11): 112514 [DOI: 10.5306/wjco.v16.i11.112514]
Corresponding Author of This Article
Wei-Qiang Zhou, PhD, Dean, Professor, Department of Pathogen Biology, Shenyang Medical College, No. 146 North Huanghe Street, Shenyang 110034, Liaoning Province, China. zhouwq@hotmail.com
Research Domain of This Article
Oncology
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Basic Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 24, 2025 (publication date) through Nov 21, 2025
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Publication Name
World Journal of Clinical Oncology
ISSN
2218-4333
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Han H, Guo XY, Wen JX, Zhao XM, Zhou WQ. Immune regulation of Chidamide-induced Linc01010 accumulation in breast cancer cell death. World J Clin Oncol 2025; 16(11): 112514 [DOI: 10.5306/wjco.v16.i11.112514]
World J Clin Oncol. Nov 24, 2025; 16(11): 112514 Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.112514
Immune regulation of Chidamide-induced Linc01010 accumulation in breast cancer cell death
Han Han, Xiao-Yun Guo, Jia-Xin Wen, Xiao-Ming Zhao, Wei-Qiang Zhou
Han Han, Department of Biochemistry and Molecular Biology, Shenyang Medical College, Shenyang 110034, Liaoning Province, China
Xiao-Yun Guo, Jia-Xin Wen, Xiao-Ming Zhao, Wei-Qiang Zhou, Department of Pathogen Biology, Shenyang Medical College, Shenyang 110034, Liaoning Province, China
Author contributions: Han H and Zhou WQ participated in the design of the study and analyzed data; Zhou WQ wrote the manuscript; all authors performed the experiments, reviewed and participated in the manuscript revision.
Supported by Natural Science Combination Foundation for Improving Innovation of Liaoning Province, No. 2022-NLTS-14-01.
Institutional review board statement: This study complied with the relevant regulations of the institution and allowed for relevant experiments to be conducted.
Institutional animal care and use committee statement: The animal experiments involved in this study complied with the relevant regulations of the institution and were allowed to be conducted.
Conflict-of-interest statement: The authors declare no conflict of interest, financial or otherwise.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: We are willing to share the relevant experimental results with data.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Qiang Zhou, PhD, Dean, Professor, Department of Pathogen Biology, Shenyang Medical College, No. 146 North Huanghe Street, Shenyang 110034, Liaoning Province, China. zhouwq@hotmail.com
Received: July 29, 2025 Revised: August 12, 2025 Accepted: October 13, 2025 Published online: November 24, 2025 Processing time: 115 Days and 1.4 Hours
Core Tip
Core Tip: Breast cancer is a prevalent malignant tumor among women. This study screened the positive long chain non-coding RNA molecule Linc01010 which can counteract the pharmacological effects of Chidamide. While investigating the effects of the Chidamide-Linc01010-mitogen-activated protein kinase kinase 6-programmed death-ligand 1 axis on the immune cell line natural killer-92, we observed that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) secretion was significantly inhibited by this response axis. Furthermore, reducing TRAIL secretion within the tumor microenvironment diminished the death effects in breast cancer cells induced by Chidamide. Our study provides a robust foundation for improving the effectiveness of current anti-breast cancer medications and for identifying new targets related to drug resistance.
