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World J Clin Oncol. May 24, 2024; 15(5): 603-613
Published online May 24, 2024. doi: 10.5306/wjco.v15.i5.603
Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers
Zheng-Long Wu, Ying Wang, Xiao-Yuan Jia, Yi-Gang Wang, Hui Wang
Zheng-Long Wu, Ying Wang, Xiao-Yuan Jia, Yi-Gang Wang, Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China
Zheng-Long Wu, Hui Wang, Department of Oncology, Zhejiang Xiaoshan Hospital, Hangzhou 311201, Zhejiang Province, China
Author contributions: Wu ZL performed the majority of the writing, prepared the figures and tables; Wang Y coordinated the writing of the paper Wang H provided the input in writing the paper; Jia XY and Wang YG contributed to the conception and design of the paper, literature review, critical revision and approval of the final version.
Supported by the Hangzhou Medical Health Science and Technology Project, No. B20220173; the Public Welfare Technology Project of Zhejiang Province, No. LGF21H160033; and Zhejiang Medical Technology Plan Project, No. 2021KY047.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Gang Wang, PhD, Professor, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928 2nd Street, Qiantang District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com
Received: January 3, 2024
Revised: March 20, 2024
Accepted: April 17, 2024
Published online: May 24, 2024
Processing time: 139 Days and 4.8 Hours
Core Tip

Core Tip: Delve into a comprehensive review spotlighting receptor tyrosine kinase-like orphan receptor 1 (ROR1) pivotal involvement in gastrointestinal cancer advancement and its promising prospects as an anti-tumor remedy. Explore pivotal cellular pathways governing ROR1 regulation and pertinent insights into existing commercial therapeutic offerings. Emphasizing ROR1’s crucial role in gastrointestinal cancer treatment, this review offers a nuanced blend of historical context and scientific insight, illuminating the dynamic landscape of this evolving field.