©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jul 24, 2021; 12(7): 507-521
Published online Jul 24, 2021. doi: 10.5306/wjco.v12.i7.507
Published online Jul 24, 2021. doi: 10.5306/wjco.v12.i7.507
Proteoglycans and their functions in esophageal squamous cell carcinoma
Yun Zhu, Annie Lai Man Cheung, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
Author contributions: Zhu Y and Cheung ALM contributed to the writing, literature review, and/or critical revision of the manuscript; Zhu Y is specially credited with design and preparation of the figures.
Supported by Research Grants Council of the Hong Kong SAR , China, No. 17111016 and No. 17100819.
Conflict-of-interest statement: The authors report no conflict of interest and no financial disclosures.
Corresponding author: Annie Lai Man Cheung, BSc, PhD, Associate Professor, School of Biomedical Sciences, The University of Hong Kong, Laboratory Block, No. 21 Sassoon Road, Hong Kong, China. lmcheung@hku.hk
Received: February 5, 2021
Peer-review started: February 5, 2021
First decision: March 31, 2021
Revised: April 13, 2021
Accepted: June 2, 2021
Article in press: June 2, 2021
Published online: July 24, 2021
Processing time: 166 Days and 5.6 Hours
Peer-review started: February 5, 2021
First decision: March 31, 2021
Revised: April 13, 2021
Accepted: June 2, 2021
Article in press: June 2, 2021
Published online: July 24, 2021
Processing time: 166 Days and 5.6 Hours
Core Tip
Core Tip: Esophageal squamous cell carcinoma (ESCC) is a highly malignant human cancer because of its early metastasis and late diagnosis. Cancer metastasis involves multiple steps that involve cell-cell and cell-matrix interactions in the tumor microenvironment. Proteoglycans are one of the components of the extracellular matrix that play an important role in cell-matrix interactions. We herein summarize the proteo