Deep diving in the PACIFIC: Practical issues in stage III non-small cell lung cancer to avoid shipwreck

Core Tip

Core Tip: Durvalumab consolidation therapy is the new standard of care in patients with unresectable stage III non-small cell lung cancer treated with concomitant chemoradiotherapy. In the PACIFIC trial, durvalumab significantly improved both progression-free survival and overall survival compared to placebo, with a manageable toxicity profile. However, several questions surrounding the clinical implementation of this therapy remain including optimal patient selection and timing of treatment initiation, programmed cell death ligand 1 determination, and the impact on clinical routines. These questions make interdisciplinary decision-making more necessary than ever. This review assesses these issues and future challenges from a multidisciplinary approach.