Wang Y, Yang XN, Ji S, Zhang YM, Wang Y, Wang YM, Gu YX. Compound lidocaine cream with warm compress for pain relief in ultrasound-guided peripherally inserted central catheter placement for cancer patients. World J Clin Oncol 2025; 16(7): 108173 [DOI: 10.5306/wjco.v16.i7.108173]
Corresponding Author of This Article
Yue-Xia Gu, Chief Nurse, Department of Nursing, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, No. 1279 Sanmen Road, Hongkou District, Shanghai 200434, China. shdsyy_guyuexia@163.com
Research Domain of This Article
Nursing
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jul 24, 2025; 16(7): 108173 Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.108173
Compound lidocaine cream with warm compress for pain relief in ultrasound-guided peripherally inserted central catheter placement for cancer patients
Yan Wang, Xue-Ni Yang, Sheng Ji, Yu-Mei Zhang, Yi Wang, Yan-Mei Wang, Yue-Xia Gu
Yan Wang, Xue-Ni Yang, Yu-Mei Zhang, Yi Wang, Yan-Mei Wang, Yue-Xia Gu, Department of Nursing, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200434, China
Sheng Ji, School of Nursing and Health Management, Shanghai University of Medicine and Health Science, Shanghai 201318, China
Author contributions: Wang Y contributed in analysis of the data and writing of the manuscript; Yang XN, Ji S, Zhang YM, Wang Y, and Wang YM collected the data and corrected the paper; Gu YX designed the study; and all authors have read and approved the final manuscript.
Supported by the Discipline Promotion Program of Shanghai Fourth People’s Hospital, No. SY-XKZT-2021-2006.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Shanghai Fourth People’s Hospital, approval No. 2025030-001.
Informed consent statement: This retrospective study integrated clinical data from electronic health records. Before all the operations were carried out, individual informed consent forms were obtained.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The de-identified datasets generated and analyzed during the current study are available from the corresponding author on reasonable request. Data sharing is subject to a formal data use agreement to ensure compliance with ethical standards.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue-Xia Gu, Chief Nurse, Department of Nursing, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, No. 1279 Sanmen Road, Hongkou District, Shanghai 200434, China. shdsyy_guyuexia@163.com
Received: April 9, 2025 Revised: April 22, 2025 Accepted: June 4, 2025 Published online: July 24, 2025 Processing time: 106 Days and 17.8 Hours
Abstract
BACKGROUND
Ultrasound-guided peripherally inserted central catheter (PICC) placement is vital for cancer therapy, but lidocaine infiltration faces limitations like puncture pain and vasospasm.
AIM
To assess the clinical efficacy of a no-pain intervention-combining compound lidocaine cream with warm compress-in reducing pain during ultrasound-guided PICC placement in cancer patients.
METHODS
A retrospective cohort study analyzed 88 cancer patients undergoing PICC placement (Shanghai Fourth People’s Hospital, 2024). Patients were divided into control (lidocaine infiltration, n = 44) and intervention (cream + warm compress, n = 44) groups. Primary outcomes: Pain scores (numerical rating scale), procedural time, complications; secondary outcome: Satisfaction.
RESULTS
The intervention group showed significantly lower pain scores (1.2 ± 0.4 vs 3.8 ± 1.2, P = 0.012) with comparable first-attempt success (95.5% vs 90.9%) and safety (P = 0.672). Thermal activation of transient receptor potential vanilloid 1 channel enhanced drug penetration, achieving anesthesia within 8-10 minutes. Patient satisfaction reached 97.7%.
CONCLUSION
The combination of compound lidocaine cream with warm compress significantly alleviates procedural pain and enhances patient satisfaction during ultrasound-guided PICC placement in cancer patients, supporting its clinical application.
Core Tip: This study presents a non-invasive analgesic protocol that combines compound lidocaine cream (2.5% lidocaine + 2.5% prilocaine) with a 40-45 °C thermal compress to mitigate pain during ultrasound-guided peripherally inserted central catheter placement in cancer patients. By leveraging thermos responsive mechanisms to enhance transdermal drug penetration, this method achieves dermal anesthesia within 8-10 minutes, effectively reducing initial puncture pain and minimizing the risk of vasospasm associated with traditional lidocaine infiltration. A retrospective analysis of 88 patients revealed significantly lower pain scores and a high level of patient satisfaction (97.7%), while maintaining procedural success rates comparable to conventional methods. Mechanistically, the thermal activation of transient receptor potential vanilloid 1 channel may facilitate deeper drug diffusion, providing rapid analgesia for urgent oncology interventions.
