Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2024; 15(9): 1239-1244
Published online Sep 24, 2024. doi: 10.5306/wjco.v15.i9.1239
Large-cell neuroendocrine carcinoma of the bladder: A case report
Yu Zhou, Lin Yang
Yu Zhou, Lin Yang, Department of Urology, Bishan Hospital Affiliated to Chongqing Medical University, Chongqing 402760, China
Author contributions: Zhou Y was responsible for the data collection and manuscript composition; Yang L played a pivotal role in critically revising the manuscript for important intellectual content, ensuring the accuracy and integrity of the work; All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Yang, MD, PhD, Chief Doctor, Chief Physician, Doctor, Occupational Physician, Surgeon, Teacher, Department of Urology, Bishan Hospital Affiliated to Chongqing Medical University, No. 9 Shuangxing Avenue, Bishan District, Chongqing, Chongqing 402760, China. 284835248@qq.com
Received: April 21, 2024
Revised: May 26, 2024
Accepted: June 12, 2024
Published online: September 24, 2024
Processing time: 129 Days and 16.2 Hours
Abstract
BACKGROUND

Bladder neuroendocrine tumors are few and exhibit a high degree of aggressiveness. The bladder is characterized by four distinct forms of neuroendocrine tumors. Among them, large-cell neuroendocrine carcinoma is the least prevalent, but has the highest level of aggressiveness. The 5-year survival rate for large-cell neuroendocrine carcinoma of the bladder is exceedingly poor. To date, only a few dozen cases have been reported.

CASE SUMMARY

Here, we report the case of a 65-year-old man with large-cell neuroendocrine carcinoma of the bladder. The patient presented to the Department of Urology at our hospital due to the presence of painless hematuria without any identifiable etiology. During hospitalization, abdominal computed tomography revealed the presence of an irregular mass on the right anterior wall of the bladder. A cystoscopic non-radical resection of the bladder lesion was performed. The postoperative pathological examination revealed large-cell neuroendocrine bladder cancer. Previous reports on cases of large-cell neuroendocrine carcinoma cases were retrieved from PubMed, and the present paper discusses the currently recognized best diagnostic and treatment options for large-cell neuroendocrine carcinoma based on the latest research progress.

CONCLUSION

Large-cell neuroendocrine carcinoma of the bladder is an uncommon malignancy with a highly unfavorable prognosis. Despite ongoing efforts to prolong patient survival through multidisciplinary therapy, the prognosis remains unfavorable. Large-cell neuroendocrine carcinoma continues to be a subject of uncertainty.

Keywords: Large-cell neuroendocrine carcinoma of the bladder; Clinical symptoms; Treatment; Prognosis; Case report

Core Tip: This report presents a case of large-cell neuroendocrine carcinoma of the bladder. This tumor is extremely rare and has been poorly reported in the medical literature, highlighting the need for early diagnosis and multimodal treatment. The report emphasizes that, although large-cell neuroendocrine carcinoma is clinically rare, it is extremely aggressive. Most patients have a very poor prognosis, although spontaneous remission is possible. There is thus considerable uncertainty surrounding this tumor.