Zhang XY, Yu JF, Li Y, Li P. Periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1: A case report. World J Clin Oncol 2024; 15(9): 1222-1231 [DOI: 10.5306/wjco.v15.i9.1222]
Corresponding Author of This Article
Yang Li, Doctor, MD, Professor, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Tianjin 300192, China. yizhiliyang@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Sep 24, 2024; 15(9): 1222-1231 Published online Sep 24, 2024. doi: 10.5306/wjco.v15.i9.1222
Periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1: A case report
Xiao-Yu Zhang, Jian-Fa Yu, Yang Li, Ping Li
Xiao-Yu Zhang, The First Central Hospital Clinical School, Tianjin Medical University, Tianjin 300192, China
Jian-Fa Yu, Yang Li, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China
Ping Li, Clinical School of the Second People’s Hospital, Tianjin Medical University, Tianjin 300192, China
Ping Li, Department of Hepatology, Tianjin Second People’s Hospital, Tianjin 300192, China
Co-corresponding authors: Yang Li and Ping Li.
Author contributions: Zhang XY, Li Y, and Li P contributed to conception and design; Zhang XY contributed to clinical data collection, literature research, and original draft preparation; Yu JF contributed to software data analysis; Li Y and Li P contributed to patient screening, enrollment, diagnosis, and treatment; Li Y was responsible for the collection of the tissue samples and supervised the whole process of publication, including the submission of the first and revised version of the manuscript; Li P was responsible for the preparation of the figures, tables, and relevant files and performed the comprehensive literature research and revised the discussion; Li Y and Li P gave detailed guidance to this paper, which was of great significance. Therefore, they are both co-corresponding authors. All authors revised the manuscript and approved the final version.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Li, Doctor, MD, Professor, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Tianjin 300192, China. yizhiliyang@163.com
Received: February 27, 2024 Revised: July 25, 2024 Accepted: July 29, 2024 Published online: September 24, 2024 Processing time: 183 Days and 19.4 Hours
Abstract
BACKGROUND
Patients with neurofibromatosis type 1 (NF1) are exposed to a higher risk of developing neuroendocrine tumors (NETs). Periampullary neuroendocrine neoplasms (NENs) in NF1 patients primarily affect the duodenum and periampullary region.
CASE SUMMARY
A 50-year-old male patient was admitted to our hospital due to progressive skin and scleral yellowing for over 6 months. An abdominal contrast-enhanced computed tomography scan revealed a tumor in the periampullary region, which measured 1.2 cm × 1.4 cm in size and showed a progressive enhancement. Magnetic resonance cholangiopancreatography indicated the dilation of intrahepatic and extrahepatic bile ducts. The patient was diagnosed with an ampullary tumor with the possibility of malignancy. A Whipple procedure was performed. Microscopically, the duodenum tumor was found to invade the mucosa, sphincter, and muscular layer of the duodenal papilla. Histologic hematoxylin and eosin staining confirmed the presence of duodenal G1 NET. Subsequently, a bibliometric analysis was performed to evaluate the state of NEN research. Publications about periampullary NENs showed an annual increase, with most of them focusing on the treatment and diagnosis of NENs.
CONCLUSION
This article reported a case of periampullary duodenal NET in a patient with NF1, and a bibliometric analysis was conducted.
Core Tip: Patients with neurofibromatosis type 1 (NF1) are exposed to a higher risk of developing neuroendocrine tumors. Periampullary neuroendocrine neoplasms in NF1 patients primarily affect the duodenum and periampullary region. This article reported a case of periampullary duodenal neuroendocrine tumor in a patient with NF1. A bibliometric analysis was conducted on periampullary neuroendocrine neoplasms to determine the state of the research.
