Zhang Y, Li J. Recent advancements in understanding of biological role of homeobox C9 in human cancers. World J Clin Oncol 2024; 15(9): 1168-1176 [PMID: PMC11438841 DOI: 10.5306/wjco.v15.i9.1168]
Corresponding Author of This Article
Jing Li, MD, Doctor, Department of Respiratory and Critical Care Medicine, The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University, No. 57 Zhonghua West Road, Lianyun District, Lianyungang 222042, Jiangsu Province, China. lijing82082011@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Sep 24, 2024; 15(9): 1168-1176 Published online Sep 24, 2024. doi: 10.5306/wjco.v15.i9.1168
Recent advancements in understanding of biological role of homeobox C9 in human cancers
Yong Zhang, Jing Li
Yong Zhang, Department of Clinical Laboratory, The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University, Lianyungang 222042, Jiangsu Province, China
Jing Li, Department of Respiratory and Critical Care Medicine, The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University, Lianyungang 222042, Jiangsu Province, China
Author contributions: Li J designed the work; Zhang Y wrote the manuscript; Zhang Y and Li J prepared the figures; Zhang Y drafted and revised the manuscript; both authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that there is no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jing Li, MD, Doctor, Department of Respiratory and Critical Care Medicine, The Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University, No. 57 Zhonghua West Road, Lianyun District, Lianyungang 222042, Jiangsu Province, China. lijing82082011@163.com
Received: May 16, 2024 Revised: July 14, 2024 Accepted: August 2, 2024 Published online: September 24, 2024 Processing time: 105 Days and 5.6 Hours
Abstract
Homeobox (HOX) C9, a member of the HOX family, is an important transcription factor, and it plays a significant role in various biological processes. This family of genes is highly valued for their essential roles in establishing and maintaining the body axis during embryonic development and adult tissues. Further, HOXC9 plays a central role in neuronal differentiation, angiogenesis, and adipose distribution, which are essential for the development of the nervous system, maturation of tissues and organs, and maintenance of energy balance and metabolic health. Recent research has found that abnormal HOXC9 expression is closely associated with the development and progression of various tumor types. The HOXC9 expression level can be an indicator of tumor prognosis. Therefore, elucidating the association between HOXC9 expression and its regulatory mechanisms and tumorigenesis can provide novel insights on the diagnosis and treatment of patients with cancer.
Core Tip: This paper discusses the association between abnormal homeobox (HOX) C9 expression and the occurrence and progression of various tumors, the impact of HOXC9 on the clinical pathological characteristics and prognosis of cancer patients, the role of HOXC9 in central nervous system tumors, breast cancer, bladder cancer, gastric cancer, colon cancer, non-small cell lung cancer, and thyroid papillary carcinoma, and the molecular mechanisms underlying the biological functions of HOXC9, including its interaction with other proteins and its regulation through DNA methylation.
