Guo MN, Jalil A, Liu JY, Miao RY, Tran TA, Guan J. Tongue swelling as a manifestation of tongue metastasis from pulmonary sarcomatoid carcinoma: A case report. World J Clin Oncol 2021; 12(4): 282-289 [PMID: 33959481 DOI: 10.5306/wjco.v12.i4.282]
Corresponding Author of This Article
Meng-Ni Guo, MD, Doctor, Department of Internal Medicine, AdventHealth Orlando, 2501 N Orange Ave Ste 235, Orlando, FL 32804, United States. mengni.guo.md@adventhealth.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
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Guo MN, Jalil A, Liu JY, Miao RY, Tran TA, Guan J. Tongue swelling as a manifestation of tongue metastasis from pulmonary sarcomatoid carcinoma: A case report. World J Clin Oncol 2021; 12(4): 282-289 [PMID: 33959481 DOI: 10.5306/wjco.v12.i4.282]
World J Clin Oncol. Apr 24, 2021; 12(4): 282-289 Published online Apr 24, 2021. doi: 10.5306/wjco.v12.i4.282
Tongue swelling as a manifestation of tongue metastasis from pulmonary sarcomatoid carcinoma: A case report
Meng-Ni Guo, Anum Jalil, Jie-Ying Liu, Ruo-Yu Miao, Tien Anh Tran, Jian Guan
Meng-Ni Guo, Anum Jalil, Jie-Ying Liu, Ruo-Yu Miao, Jian Guan, Department of Internal Medicine, AdventHealth Orlando, Orlando, FL 32804, United States
Tien Anh Tran, Department of Pathology, AdventHealth Orlando, Orlando, FL 32804, United States
Author contributions: Guo MN designed the study, collected the patient's medical records, drafted and revised the manuscript; Jalil A, Liu JY and Miao RY contributed to revision of the manuscript; Tran TA contributed to pathological diagnosis, pathological pictures, revision of the manuscript, and study design; Guan J contributed to study design and the oversight of the study; all authors read and approved the final manuscript.
Informed consent statement: All authors carefully protected the patient’s anonymity. The patient signed an informed consent allowing the publication of this case report and any other related publication.
Conflict-of-interest statement: The authors report no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng-Ni Guo, MD, Doctor, Department of Internal Medicine, AdventHealth Orlando, 2501 N Orange Ave Ste 235, Orlando, FL 32804, United States. mengni.guo.md@adventhealth.com
Received: January 7, 2021 Peer-review started: January 7, 2021 First decision: February 15, 2021 Revised: February 19, 2021 Accepted: March 24, 2021 Article in press: March 24, 2021 Published online: April 24, 2021 Processing time: 102 Days and 23.7 Hours
Abstract
BACKGROUND
Sarcomatoid carcinoma is a rare subtype of non-small-cell lung cancer, commonly associated with locally advanced disease, early metastasis, and poor prognosis. Tongue metastasis from lung cancer is a rare condition that may occur in advanced stage of the disease.
CASE SUMMARY
The patient was a 70-year-old female with a history of resected pulmonary sarcomatoid carcinoma (PSC) who presented with subacute tongue swelling, imparting the clinical impression of a lingual abscess. However, histologic examination of the partial glossectomy revealed a high-grade, poorly differentiated spindle and epithelioid carcinoma consistent with metastatic PSC.
CONCLUSION
Although uncommon, clinicians should be cognizant of the possibility of a metastatic process to the tongue mimicking a benign or inflammatory process. A high index of suspicion for metastatic disease should be maintained when tongue swelling is observed in patients with a known history of PSC.
Core Tip: Tongue metastasis from pulmonary sarcomatoid carcinoma is an uncommon phenomenon. A high index of suspicion for metastatic disease should be maintained in patients with a known history of pulmonary sarcomatoid carcinoma when tongue swelling or radiologic image indicating a lesion in the tongue, especially near the tongue base, is observed, and appropriate investigations should be undertaken.
