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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 113728
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.113728
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.113728
Double-hit primary high-grade gastric B-cell lymphoma presenting with pancytopaenia and atraumatic back pain: A case report
Michele Yi Fu, Kevin Jia, Christina Lee, Robert Sean O'Neill, Cynthuja Thilakanathan, Ian Turner, Department of Gastroenterology and Hepatology, Campbelltown Hospital, Campbelltown 2560, New South Wales, Australia
Robert Sean O'Neill, South West Clinical School, The University of New South Wales, Sydney 2052, New South Wales, Australia
Cynthuja Thilakanathan, Ian Turner, Department of Gastroenterology and Hepatology, Liverpool Hospital, Sydney 2170, New South Wales, Australia
Ian Turner, Macarthur Clinical School, Western Sydney University, Sydney 2560, New South Wales, Australia
Author contributions: Fu MY, Jia K, Lee C, O'Neill RS, Thilakanathan C, and Turner I contributed to the formulation of the manuscript, read and approved the final version of the manuscript to be published.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Robert Sean O'Neill, Department of Gastroenterology and Hepatology, Campbelltown Hospital, Therry Road, Campbelltown 2560, New South Wales, Australia.
Received: September 2, 2025
Revised: October 7, 2025
Accepted: December 3, 2025
Published online: March 5, 2026
Processing time: 162 Days and 20.3 Hours
Revised: October 7, 2025
Accepted: December 3, 2025
Published online: March 5, 2026
Processing time: 162 Days and 20.3 Hours
Core Tip
Core Tip: “Double-hit” primary gastric high-grade B-cell lymphoma is a rare variant of B-cell lymphoma that can present quite aggressively and is associated with significant morbidity and potential mortality. Endoscopically, these lesions can present as a polypoid mass, ulceration or prominent mucosal folds, and, in the absence of clinical suspicion, can be easily missed. Timely diagnosis via endoscopy and treatment is important to ensure positive outcomes; however, the literature is limited with regard to the prognosis of “double-hit” primary gastric high-grade B-cell lymphoma compared to its nodal and extra-nodal counterparts.