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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 113444
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.113444
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.113444
Mechanism of Xiaozhiling injection in the treatment of internal hemorrhoids based on changes in perianal blood flow and rectal submucosal fibers
Shu-Yan Huang, Wei-Gan Lin, Hong Lan, Zuan-Fang Li, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China
Zhen-Guo Xu, Xia-Xia Zheng, Xian-Bao Liu, Min-Hui Ke, Department of Proctology, The Second People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China
You-Min Cheng, Fujian Academy of Chinese Medical Sciences, Fuzhou 350003, Fujian Province, China
Author contributions: Ke MH, Huang SY, Lin WG, and Lan H writing of the manuscript; Ke MH, Huang SY, Zheng XX, and Liu XB were responsible for the experimental design; Lin WG and Lan H participated in the experimental research and data analysis; Huang SY and Cheng YM participated in animal model establishment; Xu ZG participated in the pathological data analysis; Li ZF participated in the blood flow data analysis. All the authors reviewed the manuscript.
Institutional animal care and use committee statement: The rats were raised in the Laboratory Animal Center of Fujian University of Chinese Medicine (No. FJATCM-IAEC2018015).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min-Hui Ke, Department of Proctology, The Second People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, Fujian Province, China. 48330132@qq.com
Received: August 26, 2025
Revised: September 15, 2025
Accepted: December 19, 2025
Published online: March 5, 2026
Processing time: 169 Days and 17 Hours
Revised: September 15, 2025
Accepted: December 19, 2025
Published online: March 5, 2026
Processing time: 169 Days and 17 Hours
Core Tip
Core Tip: Xiaozhiling injection exerts its prominent therapeutic efficacy by potently stimulating the proliferation of collagen fibres within the submucosal layer of the hemorrhoidal tissue, which in turn remodels the originally loose and disorganized connective tissue into a compact, well-aligned structure. This targeted tissue-modulating mechanism not only alleviates the key symptoms of internal haemorrhoids but also holds great promise for paving a novel, minimally invasive therapeutic avenue for this prevalent anorectal disorder.