Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 112588
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.112588
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.112588
Liver clock: Malalignment and entrainment therapeutics
Shaiphali Sharma, Department of Physiology, King George Medical College, Lucknow 226014, Uttar Pradesh, India
Shreya Pandey, Ajay Kumar Mishra, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Co-first authors: Shaiphali Sharma and Shreya Pandey.
Author contributions: Sharma S and Pandey S have played important roles in manuscript preparation as co-first authors; Mishra AK wrote manuscript; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ajay Kumar Mishra, Assistant Professor, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raibareilly Road, Lucknow 226014, Uttar Pradesh, India. ajaymishrapandit@gmail.com
Received: August 4, 2025
Revised: September 26, 2025
Accepted: December 12, 2025
Published online: March 5, 2026
Processing time: 195 Days and 9.8 Hours
Revised: September 26, 2025
Accepted: December 12, 2025
Published online: March 5, 2026
Processing time: 195 Days and 9.8 Hours
Core Tip
Core Tip: Liver clock is peripheral clock of hepatocytes concerned with metabolic genes and functions. It is desynchronised to central clock in metabolic and life style disorders. It can be resynchronised by various life style and therapeutic measures including modifying eating behaviours, light exposure, excercise or activity modification. This mini-review discusses causes of misalignment of liver clock and how to fix them.