Mehta R, Patel A, Vyas B, Desai B, Adhvaryu D, Sojitra P, Bhuptani S. L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin. World J Gastrointest Pharmacol Ther 2025; 16(4): 111977 [DOI: 10.4292/wjgpt.v16.i4.111977]
Corresponding Author of This Article
Rajiv Mehta, Department of Gastroenterology, SIDS Hospital and Research Centre, Surat Institute of Digestive Sciences, Khatodra-Bamroli Road, Surat 395002, Gujarat, India. rmgastro@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Simple Bhuptani, Department of Histopathology, Histopathology and Cytology, Surat 395019, Gujarāt, India
Author contributions: Mehta R designed the study and conceptualized and supervised the project; Vyas B and Desai B performed the experiments; Mehta R, Patel A, Adhvaryu D, Bhuptani S, and Sojitra P acquired and analyzed the data and wrote the manuscript; Mehta R revised the manuscript; Bhuptani S performed critical review of the histopathological analyses; Vyas B provided statistical support; all authors read and approved the final version of the manuscript.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the Care and Use of Laboratory Animals. It has cleared Institutional Animal Ethics Committee -IAEC (Protocol No.: MPC/IAEC/11/2022, Date of meeting: 10/12/2022).
Conflict-of-interest statement: All authors have declared no conflicts of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rajiv Mehta, Department of Gastroenterology, SIDS Hospital and Research Centre, Surat Institute of Digestive Sciences, Khatodra-Bamroli Road, Surat 395002, Gujarat, India. rmgastro@yahoo.com
Received: July 15, 2025 Revised: August 13, 2025 Accepted: November 13, 2025 Published online: December 5, 2025 Processing time: 144 Days and 2.5 Hours
Core Tip
Core Tip: Combination therapy with pirfenidone and simvastatin significantly attenuated inflammation, fibrosis, and oxidative stress in an L-arginine-induced mouse model of chronic pancreatitis. The synergistic action led to reduced tumor necrosis factor-alpha, transforming growth factor-beta 1, and lipid peroxidation levels, along with a preservation of pancreatic tissue architecture. The combination therapy also enhanced antioxidant defense as evidenced by increased glutathione peroxidase 1 activity, indicating mitigation of oxidative damage. These findings highlighted a promising strategy targeting multiple pathological pathways, namely inflammatory, fibrotic, and oxidative stress mechanisms, and supported further evaluation of this combination in translational and clinical studies for chronic pancreatitis.
