Targeted nanoliposomal nutrient delivery for human health

doi:10.4292/wjgpt.v16.i4.111502

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Dec 5, 2025 (publication date) through Dec 9, 2025

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Dec 5, 2025; 16(4): 111502
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.111502

Targeted nanoliposomal nutrient delivery for human health

Joseph Mercola

Joseph Mercola, Midwestern University, Downers Grove, IL 60515, United States

Author contributions: Mercola J was the sole author responsible for study conception and design, data acquisition and interpretation, manuscript preparation and revision, final approval of the version to be published, and agrees to be accountable for the integrity of the work in all respects.

Conflict-of-interest statement: I have no conflicts to disclose.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Joseph Mercola, Researcher, Midwestern University, 555 31^st Street, Downers Grove, IL 60515, United States. drm@mercola.com

Received: July 1, 2025
Revised: July 16, 2025
Accepted: October 10, 2025
Published online: December 5, 2025
Processing time: 157 Days and 14.3 Hours

Core Tip

Core Tip: By enclosing nutrients in nanoscale liposomes, this review shows how bioavailability leaps past gastric destruction, intestinal mucus, and first-pass metabolism while programmable surfaces steer payloads directly to kidneys, brain, or even mitochondria via ligands such as SS-31. The authors detail pH-responsive, fusogenic designs that escape endosomes, contrast natural lipid shells with immunogenic PEGylation, and map translational paths from coenzyme Q₁₀ to heavy-metal chelation. Together, targeted nanoliposomal delivery promises drug-level precision nutrition without drug-level costs, redefining supplement science.