Agrawal H, Agarwal N, Gupta N. Enteric nervous system as a therapeutic target in gastrointestinal disorders. World J Gastrointest Pharmacol Ther 2025; 16(4): 110843 [DOI: 10.4292/wjgpt.v16.i4.110843]
Corresponding Author of This Article
Nikhil Gupta, MD, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Research Domain of This Article
Gastroenterology & Hepatology
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Systematic Reviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 5, 2025 (publication date) through Dec 9, 2025
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Publication Name
World Journal of Gastrointestinal Pharmacology and Therapeutics
ISSN
2150-5349
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Agrawal H, Agarwal N, Gupta N. Enteric nervous system as a therapeutic target in gastrointestinal disorders. World J Gastrointest Pharmacol Ther 2025; 16(4): 110843 [DOI: 10.4292/wjgpt.v16.i4.110843]
World J Gastrointest Pharmacol Ther. Dec 5, 2025; 16(4): 110843 Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.110843
Enteric nervous system as a therapeutic target in gastrointestinal disorders
Himanshu Agrawal, Nitin Agarwal, Nikhil Gupta
Himanshu Agrawal, Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Delhi 110095, India
Nitin Agarwal, Department of Surgical Disciplines, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, Delhi 110001, India
Nikhil Gupta, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Delhi 110001, India
Co-first authors: Himanshu Agrawal and Nikhil Gupta.
Author contributions: Agrawal H, Gupta N, and Agarwal N contributed to research conception and design; Agrawal H, Gupta N, and Agarwal N contributed to data acquisition; Agrawal H, Gupta N, and Agarwal N contributed to data analysis and interpretation; Agrawal H and Gupta N contributed to drafting of the manuscript; Agrawal H, Gupta N, and Agarwal N contributed to critical revision of the manuscript; Agrawal H, Gupta N, and Agarwal N contributed to supervision; Agrawal H, Gupta N, and Agarwal N contributed to approval of the final manuscript.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nikhil Gupta, MD, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Received: June 17, 2025 Revised: July 14, 2025 Accepted: October 23, 2025 Published online: December 5, 2025 Processing time: 172 Days and 1.7 Hours
Core Tip
Core Tip: The enteric nervous system (ENS) serves as a pivotal regulatory system within the gastrointestinal tract. Dysfunction in the ENS has been linked to a range of gastrointestinal disorders, including irritable bowel syndrome, gastroparesis, and inflammatory bowel diseases. Advances in therapeutic approaches targeting ENS pathways—ranging from neurotransmitter modulation to gene therapy—hold great promise for improving patient outcomes. By leveraging the gut-brain axis and focusing on restoring neural and glial cell function, these therapies represent a new frontier in gastrointestinal medicine. Targeting the ENS could offer a more effective, individualized approach to managing complex gastrointestinal diseases, providing significant improvements in symptom management and quality of life for affected patients.
