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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Dec 5, 2025; 16(4): 109304
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.109304
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.109304
Evolving role of radiation therapy in advanced/metastatic intrahepatic cholangiocarcinoma
Deepti Sharma, Department of Radiation Oncology, Institute of Liver and Biliary Sciences, New Delhi 110070, India
Babu Lal Meena, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Co-first authors: Deepti Sharma and Babu Lal Meena.
Author contributions: Sharma D and Meena BL contributed equally to the article's concept, design, and writing; both authors approved the manuscript and its submission to the journal.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed following the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deepti Sharma, Associate Professor, Department of Radiation Oncology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Received: May 7, 2025
Revised: May 30, 2025
Accepted: August 27, 2025
Published online: December 5, 2025
Processing time: 212 Days and 19.3 Hours
Revised: May 30, 2025
Accepted: August 27, 2025
Published online: December 5, 2025
Processing time: 212 Days and 19.3 Hours
Core Tip
Core Tip: This review explores the transformative role of radiation therapy, including stereotactic body radiation therapy (SBRT), in managing intrahepatic cholangiocarcinoma, an aggressive malignancy with limited treatment options. With advances in radiation delivery, motion management, and systemic therapy integration, SBRT is evolving beyond palliation to improve local control, survival outcomes, and potential synergy with transplantation strategies.