Copyright
©The Author(s) 2021.
World J Gastrointest Pathophysiol. May 22, 2021; 12(3): 40-50
Published online May 22, 2021. doi: 10.4291/wjgp.v12.i3.40
Published online May 22, 2021. doi: 10.4291/wjgp.v12.i3.40
Table 1 Baseline demographics
Training (n = 715) | Validation (n = 312) | P value | |
Age (yr) | 45.6 (10.7) | 44.5 (11.1) | 0.1 |
Male/female (%) | 66/34 | 66/34 | 1.0 |
Platelets (× 109/L) | 186.7 (64.4) | 190.6 (68.2) | 0.4 |
Alanine aminotransferase (IU/L) | 103.8 (88.1) | 105.1 (89.1) | 0.8 |
Aspartate aminotransferase (IU/L) | 69.9 (55.0) | 68.0 (53.3) | 0.6 |
Albumin (g/dL) | 3.9 (0.46) | 3.9 (0.39) | 0.2 |
Alkaline phosphatase (IU/L) | 82.3 (39.2) | 79.0 (29.2) | 0.1 |
Prothrombin time (s) | 13.0 (1.3) | 12.9 (1.1) | 0.3 |
Total bilirubin (mg/dL) | 0.81 (0.48) | 0.77 (0.45) | 0.2 |
Ishak fibrosis | 2.4 (1.8) | 2.3 (1.7) | 0.3 |
HAI inflammation | 8.0 (3.0) | 7.9 (3.1) | 0.5 |
HBV/HCV/HDV (%) | 23/68/8 | 23/68/9 | 1.0 |
Table 2 Spearman correlations between Ishak fibrosis and liver tests within training cohort
R | P value | |
Platelets | -0.49 | < 0.0001 |
AST | 0.51 | < 0.0001 |
ALT | 0.37 | < 0.0001 |
Alkaline phosphatase | 0.35 | < 0.0001 |
Prothrombin time | 0.33 | < 0.0001 |
Albumin | -0.30 | < 0.0001 |
Total bilirubin | 0.18 | < 0.0001 |
Table 3 Area under the curve using selected liver tests within the training cohort
Platelets | ALT | AST | Alkaline phosphatase | Prothrombin time |
0.86 (0.82, 0.90) | 0.65 (0.59, 0.71) | 0.76 (0.71, 0.81) | 0.76 (0.71, 0.81) | 0.77 (0.71, 0.82) |
Table 4 Performance of optimal platelet cut-offs in validation cohort
Platelet cut-off (× 109/L) | AUROC | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | |
Entire validation cohort | 143 | 0.85 (0.76-0.93) | 79 | 84 | 33 | 98 |
HBV | 143 | 0.81 (0.53-1.00) | 83 | 82 | 29 | 98 |
HCV | 143 | 0.83 (0.72-0.94) | 75 | 86 | 31 | 98 |
HDV | 143 | 0.87 (0.74-1.00) | 100 | 60 | 47 | 100 |
Table 5 Performance of platelet cut-offs in training cohort
Platelet counts (× 109/L) | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) |
130 | 67 | 91 | 57 | 94 |
140 | 73 | 86 | 48 | 95 |
143 | 74 | 83 | 44 | 94 |
150 | 78 | 78 | 38 | 95 |
- Citation: Surana P, Hercun J, Takyar V, Kleiner DE, Heller T, Koh C. Platelet count as a screening tool for compensated cirrhosis in chronic viral hepatitis. World J Gastrointest Pathophysiol 2021; 12(3): 40-50
- URL: https://www.wjgnet.com/2150-5330/full/v12/i3/40.htm
- DOI: https://dx.doi.org/10.4291/wjgp.v12.i3.40