Qasim A, Zacharia GS, Veena F, Kandhi SD, Patel H. From esophagus to colon: A narrative review of eosinophilic gastrointestinal disorders. World J Gastrointest Pathophysiol 2026; 17(1): 115307 [DOI: 10.4291/wjgp.v17.i1.115307]
Corresponding Author of This Article
George S Zacharia, DM, MD, Academic Fellow, Department of Internal Medicine, BronxCare Health System, 1650 Grand Concourse, Bronx, NY 10457, United States. george.lenx@yahoo.com
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Gastroenterology & Hepatology
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Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 22, 2026 (publication date) through Mar 20, 2026
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Publication Name
World Journal of Gastrointestinal Pathophysiology
ISSN
2150-5330
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Qasim A, Zacharia GS, Veena F, Kandhi SD, Patel H. From esophagus to colon: A narrative review of eosinophilic gastrointestinal disorders. World J Gastrointest Pathophysiol 2026; 17(1): 115307 [DOI: 10.4291/wjgp.v17.i1.115307]
World J Gastrointest Pathophysiol. Mar 22, 2026; 17(1): 115307 Published online Mar 22, 2026. doi: 10.4291/wjgp.v17.i1.115307
From esophagus to colon: A narrative review of eosinophilic gastrointestinal disorders
Abeer Qasim, George S Zacharia, FNU Veena, Sameer D Kandhi, Harish Patel
Abeer Qasim, Sameer D Kandhi, Harish Patel, Department of Gastroenterology, BronxCare Health System, Bronx, NY 10457, United States
George S Zacharia, FNU Veena, Department of Internal Medicine, BronxCare Health System, Bronx, NY 10457, United States
Co-first authors: Abeer Qasim and George S Zacharia.
Author contributions: Qasim A and Kandhi SD contributed to conceptualization, literature search and data acquisition; Qasim A and Zacharia GS contributed to data analysis and interpretation, have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; Qasim A, Zacharia GS, Veena F contributed to manuscript drafting, critical revision of the manuscript for important intellectual content; Patel H final approval of the version to be published; all authors agree to be accountable for all aspects of the work and ensure accuracy and integrity of the content.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Corresponding author: George S Zacharia, DM, MD, Academic Fellow, Department of Internal Medicine, BronxCare Health System, 1650 Grand Concourse, Bronx, NY 10457, United States. george.lenx@yahoo.com
Received: October 16, 2025 Revised: December 17, 2025 Accepted: January 27, 2026 Published online: March 22, 2026 Processing time: 157 Days and 16.8 Hours
Core Tip
Core Tip: Eosinophilic gastrointestinal disorders encompass a spectrum of chronic, immune-mediated conditions characterized by eosinophilic infiltration of the gastrointestinal tract in the absence of secondary causes. Despite its increasing prevalence, significant gaps remain in awareness, diagnosis, and treatment of the disease. The diagnosis mandates demonstration of tissue eosinophilia, typically on gastrointestinal endoscopic biopsies, together with exclusion of secondary causes. The treatment involves dietary modifications, corticosteroids, proton pump inhibitors, and emerging biologics targeting key cytokine pathways. The lack of standardized guidelines emphasizes the need for multidisciplinary care and further research to refine diagnostic thresholds and optimize treatment strategies.
