Giri S, Harindranath S, Kulkarni A, Sahoo JK, Joshi H, Nath P, Sahu MK. Fatigue in inflammatory bowel disease: Prevalence, risk factors, assessment, outcomes, and management. World J Gastrointest Pathophysiol 2025; 16(3): 107573 [DOI: 10.4291/wjgp.v16.i3.107573]
Corresponding Author of This Article
Preetam Nath, DM, MD, Professor, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Patia, Bhubaneshwar 751024, Odisha, India. drpreetamnath@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Suprabhat Giri, Preetam Nath, Manoj Kumar Sahu, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar 751024, Odisha, India
Sidharth Harindranath, Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Mumbai 400012, Maharashtra, India
Akshay Kulkarni, Department of Gastroenterology, Deenanath Mangeshkar Hospital, Pune 411004, Mahārāshtra, India
Jiten Kumar Sahoo, Division of Pediatric Gastroenterology, Department of Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneshwar 751024, Odisha, India
Harshad Joshi, Department of Gastroenterology, Gleneagles Hospital, Mumbai 400012, Maharashtra, India
Co-first authors: Suprabhat Giri and Sidharth Harindranath.
Author contributions: Giri S and Harindranath S contributed to the conception and design of the manuscript; All authors contributed to the literature review, analysis, data collection, and interpretation; Giri S, Harindranath S, Kulkarni A, and Sahu JK drafted the initial manuscript; Giri S and Harindranath S contributed to the critical revision of the initial manuscript; All the authors approved the final version of the manuscript.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Preetam Nath, DM, MD, Professor, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Patia, Bhubaneshwar 751024, Odisha, India. drpreetamnath@gmail.com
Received: March 26, 2025 Revised: April 30, 2025 Accepted: July 3, 2025 Published online: September 22, 2025 Processing time: 177 Days and 15.7 Hours
Core Tip
Core Tip: Fatigue is a prevalent and debilitating symptom in patients with inflammatory bowel disease (IBD), affecting nearly half of all patients and three-fourths with active disease. Its origins are multifactorial, involving inflammation, nutritional deficiencies, sleep issues, psychological factors, gut microbiota, muscle dysfunction, and inactivity. Identifying and addressing these factors is key to management. The IBD fatigue and functional assessment in chronic illness therapy - fatigue scales are common assessment tools for adults, with PedsQL for pediatric patients. Management involves physical exercise, medical or surgical management of active disease, correcting nutritional deficiencies, and addressing psychological and sleep disorders. Persistent fatigue may require physical and psychological interventions through a multidisciplinary approach.
