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World J Gastrointest Pathophysiol. Mar 22, 2023; 14(2): 12-20
Published online Mar 22, 2023. doi: 10.4291/wjgp.v14.i2.12
Role of T-box transcription factor 3 in gastric cancers
Naoki Asano, Akira Imatani, Akio Takeuchi, Masashi Saito, Xiao-Yi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune
Naoki Asano, Akira Imatani, Akio Takeuchi, Masashi Saito, Xiao-Yi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
Author contributions: Asano N performed the majority of the writing, prepared the figure and table, and acquired funding; Imatani A performed the writing review and the editing, and acquired funding; Takeuchi A, Saito M, and Jin XY performed data acquisition; Hatta W and Uno K performed writing review and editing; Koike T performed writing review and editing, and supervision; Masamune A performed supervision, writing review and editing.
Supported by Grants-in-Aid for Scientific Research from the Japanese Society for the Promotion of Science, No. 18K07928, No. 19K08411, and No. 22K08025.
Conflict-of-interest statement: Dr. Asano reports grants from Japan Society for the Promotion of Science, during the conduct of the study.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Naoki Asano, MD, PhD, Lecturer, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai 980-8574, Japan. asanon@med.tohoku.ac.jp
Received: December 14, 2022
Peer-review started: December 14, 2022
First decision: February 18, 2023
Revised: February 22, 2023
Accepted: March 10, 2023
Article in press: March 10, 2023
Published online: March 22, 2023
Processing time: 97 Days and 1.3 Hours
Core Tip

Core Tip: Expression of T-box transcription factor 3 (TBX3) has been reported in a variety of cancers. Preceding reports have shown that TBX3 contributes to the progression of cancers by suppressing cellular senescence and promoting epithelial-mesenchymal transition. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in aging-related gastric carcinogenesis.