Asano N, Imatani A, Takeuchi A, Saito M, Jin XY, Hatta W, Uno K, Koike T, Masamune A. Role of T-box transcription factor 3 in gastric cancers. World J Gastrointest Pathophysiol 2023; 14(2): 12-20 [PMID: 37035275 DOI: 10.4291/wjgp.v14.i2.12]
Corresponding Author of This Article
Naoki Asano, MD, PhD, Lecturer, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai 980-8574, Japan. asanon@med.tohoku.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Naoki Asano, Akira Imatani, Akio Takeuchi, Masashi Saito, Xiao-Yi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
Author contributions: Asano N performed the majority of the writing, prepared the figure and table, and acquired funding; Imatani A performed the writing review and the editing, and acquired funding; Takeuchi A, Saito M, and Jin XY performed data acquisition; Hatta W and Uno K performed writing review and editing; Koike T performed writing review and editing, and supervision; Masamune A performed supervision, writing review and editing.
Supported byGrants-in-Aid for Scientific Research from the Japanese Society for the Promotion of Science, No. 18K07928, No. 19K08411, and No. 22K08025.
Conflict-of-interest statement: Dr. Asano reports grants from Japan Society for the Promotion of Science, during the conduct of the study.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Naoki Asano, MD, PhD, Lecturer, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai 980-8574, Japan. asanon@med.tohoku.ac.jp
Received: December 14, 2022 Peer-review started: December 14, 2022 First decision: February 18, 2023 Revised: February 22, 2023 Accepted: March 10, 2023 Article in press: March 10, 2023 Published online: March 22, 2023 Processing time: 97 Days and 1.3 Hours
Abstract
The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.
Core Tip: Expression of T-box transcription factor 3 (TBX3) has been reported in a variety of cancers. Preceding reports have shown that TBX3 contributes to the progression of cancers by suppressing cellular senescence and promoting epithelial-mesenchymal transition. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in aging-related gastric carcinogenesis.
