Zinc and gastrointestinal disease

doi:10.4291/wjgp.v5.i4.496

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Nov 15, 2014; 5(4): 496-513
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.496

Zinc and gastrointestinal disease

Sonja Skrovanek, Katherine DiGuilio, Robert Bailey, William Huntington, Ryan Urbas, Barani Mayilvaganan, Giancarlo Mercogliano, James M Mullin

Sonja Skrovanek, Katherine DiGuilio, James M Mullin, Lankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA 19096, United States

Robert Bailey, Barani Mayilvaganan, Giancarlo Mercogliano, James M Mullin, Division of Gastroenterology, Lankenau Medical Center, Wynnewood, PA 19096, United States

William Huntington, Ryan Urbas, The Department of Medicine, Lankenau Medical Center, Wynnewood, PA 19096, United States

Author contributions: All authors contributed to this paper.

Correspondence to: James M Mullin, PhD, Director of Research, Division of Gastroenterology, Lankenau Medical Center, 100 Lancaster Avenue, Wynnewood, PA 19096, United States. mullinj@mlhs.org

Telephone: +1-484-4762708 Fax: +1-484-4762205

Received: May 28, 2014
Revised: September 18, 2014
Accepted: October 1, 2014
Published online: November 15, 2014
Processing time: 175 Days and 10 Hours

Abstract

This review is a current summary of the role that both zinc deficiency and zinc supplementation can play in the etiology and therapy of a wide range of gastrointestinal diseases. The recent literature describing zinc action on gastrointestinal epithelial tight junctions and epithelial barrier function is described. Zinc enhancement of gastrointestinal epithelial barrier function may figure prominently in its potential therapeutic action in several gastrointestinal diseases.

Keywords: Zinc; Tight junction; Nutrition; Nutraceutical; Micronutrient

Core tip: This is an overview of the role that both zinc deficiency and zinc supplementation can play in the etiology and therapy of a wide range of gastrointestinal diseases.