Published online Mar 22, 2022. doi: 10.4291/wjgp.v13.i2.50
Peer-review started: March 17, 2021
First decision: May 1, 2021
Revised: May 6, 2021
Accepted: January 25, 2022
Article in press: January 25, 2022
Published online: March 22, 2022
Processing time: 362 Days and 3.8 Hours
Hepatitis E virus (HEV) is a small non-enveloped single stranded RNA virus whose genotypes 3 and 4 have been associated with zoonotic transmission in industrialized countries. HEV infection is considered the main cause of acute hepatitis worldwide. In some cases, transfusion of blood components or organ transplantation have been reported as the source of infection. We have conducted a literature review on the risk of transmission through cell and tissue allografts. Although no case was found, measures to control this risk should be taken when donor profile (based upon geographical and behavioural data) recommended it. Issues to be considered in donor screening and tissue processing to assess and to reduce the risk of HEV transmission are approached.
Core Tip: This manuscript provide a novel perspective of the mode of transmission of hepatitis E virus (HEV). HEV is mainly transmitted via fecal-oral route, but in recent years other transmission routes have been reported, including blood-borne transmission. The processing of tissue allografts in duly accredited tissue banks provides safe and efficient products.