Gui H, Husson MA, Mannan R. Correlations of morphology and molecular alterations in traditional serrated adenoma. World J Gastrointest Pathophysiol 2020; 11(4): 78-83 [PMID: 32587787 DOI: 10.4291/wjgp.v11.i4.78]
Corresponding Author of This Article
Hongxing Gui, MD, PhD, Doctor, Department of Pathology and Laboratory Medicine, Pennsylvania Hospital of the University of Pennsylvania Health System, 801 Spruce Street, 10th Floor Spruce Building, Philadelphia, PA 19107, United States. hongxing.gui@uphs.upenn.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Pathophysiol. Jun 20, 2020; 11(4): 78-83 Published online Jun 20, 2020. doi: 10.4291/wjgp.v11.i4.78
Correlations of morphology and molecular alterations in traditional serrated adenoma
Hongxing Gui, Michael A Husson, Rifat Mannan
Hongxing Gui, Michael A Husson, Rifat Mannan, Department of Pathology and Laboratory Medicine, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, PA 19107, United States
Author contributions: Gui H collected, analyzed the data and drafted the manuscript; Husson MA and Mannan R critically revised and finally approved the manuscript.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hongxing Gui, MD, PhD, Doctor, Department of Pathology and Laboratory Medicine, Pennsylvania Hospital of the University of Pennsylvania Health System, 801 Spruce Street, 10th Floor Spruce Building, Philadelphia, PA 19107, United States. hongxing.gui@uphs.upenn.edu
Received: January 10, 2020 Peer-review started: January 10, 2020 First decision: January 28, 2020 Revised: March 27, 2020 Accepted: May 27, 2020 Article in press: May 27, 2020 Published online: June 20, 2020 Processing time: 158 Days and 8.2 Hours
Abstract
Traditional serrated adenoma was first reported by Longacre and Fenoglio-Presier in 1990. Their initial study described main features of this lesion, but the consensus diagnostic criteria were not widely adopted until recently. Traditional serrated adenoma presents with grossly protuberant configuration and pinecone-like appearance upon endoscopy. Histologically, it is characterized by ectopic crypt formation, slit-like serration, eosinophilic cytoplasm and pencillate nuclei. Although much is now known about the morphology and molecular changes, the mechanisms underlying the morphological alterations are still not fully understood. Furthermore, the origin of traditional serrated adenoma is not completely known. We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity.
Core tip: This mini-review summarizes recent findings of traditional serrated adenoma. The origin of traditional serrated adenoma and its molecular pathogenesis are discussed in details.
