Thanihaivel E S, Sharma A, Verma M, Vijayvergiya R, Singhal M. Evaluation of bicuspid aortic valve-associated aortopathic changes using third-generation dual-source computed tomography. World J Radiol 2026; 18(6): 120056 [DOI: 10.4329/wjr.120056]
Corresponding Author of This Article
Arun Sharma, Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Madhya Marg, Sector 12, Chandigarh 160012, Chandīgarh, India. drarungautam@gmail.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
research-article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Thanihaivel E S, Sharma A, Verma M, Vijayvergiya R, Singhal M. Evaluation of bicuspid aortic valve-associated aortopathic changes using third-generation dual-source computed tomography. World J Radiol 2026; 18(6): 120056 [DOI: 10.4329/wjr.120056]
Salai Thanihaivel E, Arun Sharma, Mansi Verma, Manphool Singhal, Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandīgarh, India
Rajesh Vijayvergiya, Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandīgarh, India
Co-corresponding authors: Arun Sharma and Manphool Singhal.
Author contributions: Thanihaivel E S and Sharma A conceptualized and designed the study and performed the research; Verma M contributed to data acquisition and analysis; Vijayvergiya R contributed to data analysis and interpretation; Singhal M supervised the study and provided critical revisions; Thanihaivel E S drafted the manuscript; Sharma A and Singhal M contribute equally to this study as co-corresponding authors; and all authors critically reviewed the manuscript and approved the final version.
AI contribution statement: The AI tool Grammarly was used for language editing (grammar, punctuation, and spelling) and polishing of the author’s text. All sections of the main text were written by the authors. No AI tool was used to draft any portion of the manuscript and response to reviewers. No AI tool was used for translation, data analysis, statistical computation, or content generation. All statistical analyses were performed in SPSS version 22 by the authors. No AI-generated images appear in the manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Ethics Committee of the Postgraduate Institute of Medical Education and Research, (Approval No. IEC-INT/2022/MD-638).
Informed consent statement: Written informed consent was taken from the patients on prescribed formats, which were available in three languages - English, Hindi and the regional language (Punjabi) as per institutional protocol.
Conflict-of-interest statement: The authors declare no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Corresponding author: Arun Sharma, Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Madhya Marg, Sector 12, Chandigarh 160012, Chandīgarh, India. drarungautam@gmail.com
Received: February 14, 2026 Revised: April 16, 2026 Accepted: May 25, 2026 Published online: June 28, 2026 Processing time: 131 Days and 13.2 Hours
Core Tip
Core Tip: Bicuspid aortic valve (BAV) is a common congenital cardiac anomaly, frequently associated with aortopathy. Using third-generation dual-source computed tomography (CT) in 100 patients, we observed ascending aortic dilatation in 87% and identified a cohort-specific aortic size index threshold of 23.8 mm/m2 associated with CT-defined ascending aortic dilatation > 40 mm (sensitivity 84%, specificity 90%). Because aortic size index (ASI) is mathematically derived from the ascending aortic diameter, it is best interpreted as a cohort-specific threshold rather than as independent validation of ASI as a predictor. CT measurements were larger than transthoracic echocardiography (mean difference 11.72 mm), although this difference likely reflects differences in measurement sites, measurement conventions, and inherent limitations of 2D echocardiography in BAV rather than simple underestimation alone. These preliminary findings support further evaluation of indexed measurements alongside absolute diameter thresholds in populations with smaller body habitus, and will require validation in independent multicentre cohorts with longitudinal outcomes.
