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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Sep 28, 2025; 17(9): 111005
Published online Sep 28, 2025. doi: 10.4329/wjr.v17.i9.111005
Published online Sep 28, 2025. doi: 10.4329/wjr.v17.i9.111005
Comprehensive linkage between molecular biology and imaging radiomics for thyroid nodules
Zhen-Xing He, Xiao-Ping Zhang, Jian-She Yang, The Third People’s Hospital of Longgang, Clinical Institute of Shantou University Medical College, Shenzhen 518115, Guangdong Province, China
Xiao-Ping Zhang, Jian-She Yang, Department of Nuclear Medicine and Oncology Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
Author contributions: Yang JS designed the overall concept and outline of the manuscript; He ZX contributed to the discussion and design of the manuscript; He ZX, Zhang XP, and Yang JS contributed to the writing and editing of the manuscript, illustrations, and literature review.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-She Yang, PhD, Academic Fellow, Chairman, Dean, Full Professor, Professor, Department of Nuclear Medicine and Oncology Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Yanchang Road, Shanghai 200072, China. 2305499@tongji.edu.cn
Received: June 23, 2025
Revised: July 23, 2025
Accepted: August 15, 2025
Published online: September 28, 2025
Processing time: 98 Days and 6.1 Hours
Revised: July 23, 2025
Accepted: August 15, 2025
Published online: September 28, 2025
Processing time: 98 Days and 6.1 Hours
Core Tip
Core Tip: Thyroid nodules are highly prevalent. Distinguishing malignant and benign thyroid nodules is critical for clinical management. Understanding the cytology, molecular biology, and imaging results of non-operated nodules, and finally building a molecular-imaging linkage model is of great importance. Among these, the molecular characteristics of thyroid nodules are critical for diagnosis and treatment. However, identifying these characteristics is costly and challenging because of unexpected technical difficulties. Bridging the essential link between molecular characteristics and the computed tomography radiomics model with existing and ongoing knowledge might resolve these challenges.